Mit den Proteaseinhibitoren der ersten Generation konnten in einer Triple-Therapie mit PEG-Interferon bei HCV-Patienten Genotyp 1 Heilungsraten von 70–75% erreicht werden. Die zweite Generation dieser Substanzen verspricht eine noch bessere Wirksamkeit bei weniger Nebenwirkungen und geringerer Resistenzbildung. Große Hoffnungen werden auch auf einen pangenotypisch wirksamen NS5B-Polymeraseinhibitor gesetzt.
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Geier, A. Was hat sich geändert? Was kommt demnächst?. MMW - Fortschritte der Medizin 155, 59–63 (2013). https://doi.org/10.1007/s15006-013-2335-5
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DOI: https://doi.org/10.1007/s15006-013-2335-5