HIV-Patienten haben häufiger eine niedrige Knochendichte, Osteopenie und Osteoporose als nicht HIV-Infizierte, begleitend auch einen Vitamin-D-Mangel und eine Niereninsuffizienz. Daher lohnt es sich, bei diesen Patienten schon relativ frühzeitig an die Messung der Knochendichte zu denken.
Literatur
Weinberg,M., Schambelan M: Bone and calcium disorders in HIV-infected patients. www.uptodate.com 2012 assessed 03.02.2012
Borderi et al: Metabolic bone disease in HIV infection. AIDS 2009; 23:1297
Brown TT et al: Antiretroviral therapy and the prevalence of osteopenia and osteoporose: a metaanalytic review. AIDS 2006; 20:2165
Bonjoch A et al: High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study. AIDS 2010; 24: 2827
Cazanave C et al: Reduced bone mineral density in HIV-infected patients: prevalence and associated factors. AIDS 2008; 22: 395
Triant VA et al: Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected Patients in a large US healthcare system. J.Clin Endocrinol Metab 2008; 93:3499
McComsey GA et al: Fragility fractures in HIV-infected patients: need for better understanding of diagnosis and management. J Int Assoc Physicians AIDS care (Chic) 2004; 3: 86
Manolagas SC, Jilka RL: Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995; 332: 305
Martin K et al: Symptomatic bone disorders in HIV-infected patients: incidence in the Aquitaine cohort (1999–2002). HIV Medicine 2004; 5: 421
Gibellini D et al: HIV-1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFalpha activation. J Med Virol 2008; 80:1507
Collier J: Bone disorders in chronic liver disease. Hepatology 2007; 46: 1271
Yin MT et al: Fracture incidence in HIV-infected women: results from the Women’s Interagency HIV Study. AIDS 2010; 24: 2679
Grund B et al: Continuous antiretrovirus therapy decreases bone mineral density. AIDS 2009; 23: 1519
Jacobson DL et al: Evolution and predictors of change in total bone mineral density over time in HIV-infected men and women in the nutrition for healthy living study. J Acquir Immune Defic Syndr 2008; 49: 298
Gallant JE et al: Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naïve patients: a 3-year randomized trial. JAMA 2004; 292: 191
http://www.retroconference.org/2009/Abstracts/33890.htm (accessed 02.02.2012)
McComsey GA et al: Bone mineral density and fractures in antiretroviral-naïve persons randomized to receive abacavir-lamivudine of tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG 5202. J Infect Dis 2011; 203: 1791
Duvivier C et al: Greater decrease in bone mineral density with protease inhibitor regimens compared with nonnucleoside reverse transcriptase inhibitor regimens in HIV-1 infected naïve patients. AIDS 2009; 23: 817
Nolan D et al: Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavir. AIDS 2001; 15: 1275
Arnsten JH et al: Decreases bone mineral density and increased fracture risk in aging men with or at risk for HIV infection. AIDS 2007; 21: 617
Van Den Bout-Van Den Beukel CJ et al: Vitamin D deficiency among HIV type 1-infected individuals in the Netherlands: effects of antiretroviral therapy. AIDS Res Hum Retroviruses 2008; 24: 1375
Kühne CA et al: Bone and mineral metabolism in human immunodeficiency virus infection. J Bone Miner Res 2001; 16:2
Mueller NJ et al: High prevalence of severe vitamin D deficiency in combined therapy-naïve and successfully treated Swiss HIV patients. AIDS 2010; 24: 1127
Cooper RD et al: Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients. Clin Infect Dis 2010; 51: 496
Fernandez-Fernandez B et al: Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat 2011; 2011: 354908, Epub 2011, Jun 7
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Goebel, FD. Die Knochendichte kann bei HIV-Patienten schon früh abnehmenachtungsstudien. MMW - Fortschritte der Medizin 154, 37–40 (2012). https://doi.org/10.1007/s15006-012-0625-y
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DOI: https://doi.org/10.1007/s15006-012-0625-y