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Tissue Engineering and Regenerative Medicine

, Volume 15, Issue 5, pp 513–520 | Cite as

Electrostatically Interactive Injectable Hydrogels for Drug Delivery

  • Ji Young Seo
  • Bong Lee
  • Tae Woong Kang
  • Jung Hyun Noh
  • Min Ju Kim
  • Yun Bae Ji
  • Hyeon Jin Ju
  • Byoung Hyun Min
  • Moon Suk Kim
Review Article
  • 56 Downloads

Abstract

Background:

Several injectable hydrogels have been developed extensively for a broad range of biomedical applications. Injectable hydrogels forming in situ through the change in external stimuli have the distinct properties of easy management and minimal invasiveness, and thus provide the advantage of bypassing surgical procedures for administration resulting in better patient compliance.

Methods:

The injectable in situ-forming hydrogels can be formed irreversibly or reversibly under physiological stimuli. Among several external stimuli that induce formation of hydrogels in situ, in this review, we focused on the electrostatic interactions as the most simple and interesting stimulus.

Results:

Currently, numerous polyelectrolytes have been reported as potential electrostatically interactive in situ-forming hydrogels. In this review, a comprehensive overview of the rapidly developing electrostatically interactive in situ-forming hydrogels, which are produced by various anionic and cationic polyelectrolytes such as chitosan, celluloses, and alginates, has been outlined and summarized. Further, their biomedical applications have also been discussed.

Conclusion:

The review concludes with perspectives on the future of electrostatically interactive in situ-forming hydrogels.

Keywords

Electrostatic interactions In situ-forming hydrogels Injectable Drug delivery Regenerative medicine 

Notes

Acknowledgement

This work was supported by the Pukyong National University Research Abroad Fund in 2014 (C-D-2014-0713).

Compliance with ethical standards

Conflicts of interest

The authors have no financial conflicts of interest.

Ethical statement

There are no animal experiments carried out for this article.

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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Molecular Science and TechnologyAjou UniversitySuwonRepublic of Korea
  2. 2.Department of Polymer EngineeringPukyong National UniversityBusanRepublic of Korea
  3. 3.Cell Therapy CenterAjou University Medical CenterSuwonRepublic of Korea

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