Tissue Engineering and Regenerative Medicine

, Volume 15, Issue 6, pp 699–709 | Cite as

Current Status of Stem Cell Treatment for Type I Diabetes Mellitus

  • Anupama Kakkar
  • Ashima Sorout
  • Mahak Tiwari
  • Pallavi Shrivastava
  • Poonam Meena
  • Sumit Kumar Saraswat
  • Supriya Srivastava
  • Rajan Datt
  • Siddharth Pandey
Review Article



Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans.


Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into β islet cells.


These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms.


Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.


Diabetes mellitus Stem cells In vitro differentiation Bone marrow 



The authors are grateful to the Datt Mediproducts Pvt. Ltd. for supporting their current research. We sincerely thank Dr. Rajan Datt for valuable scientific discussion.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interests.

Ethical statement

There are no animal expreiments carried out for this article.


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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Anupama Kakkar
    • 1
  • Ashima Sorout
    • 1
  • Mahak Tiwari
    • 1
  • Pallavi Shrivastava
    • 1
  • Poonam Meena
    • 1
  • Sumit Kumar Saraswat
    • 1
  • Supriya Srivastava
    • 1
  • Rajan Datt
    • 2
  • Siddharth Pandey
    • 1
  1. 1.Department of Life Sciences (R&D)Datt Mediproducts Pvt. Ltd.District MewatIndia
  2. 2.Datt Mediproducts Pvt Ltd.New DelhiIndia

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