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Tissue Engineering and Regenerative Medicine

, Volume 14, Issue 6, pp 653–665 | Cite as

Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases

  • Dongkyu Kim
  • Gun-Sik Cho
  • Choongseong Han
  • Dong-Hyuk Park
  • Hee-Kyung Park
  • Dong-Hun Woo
  • Jong-Hoon KimEmail author
Review Article
Part of the following topical collections:
  1. Stem cell biology

Abstract

Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.

Keywords

Liver failure Liver regeneration Stem cell transplantation Secretome 

Abbreviations

NPCs

Non-parenchymal cells

HSCs

Hepatic stellate cells

PH

Partial hepatectomy

TNF-α

Tumor necrosis factor-α

IL-6

Interleukin-6

HGF

Hepatocyte growth factor

EGF

Epidermal growth factor

FGF

Fibroblast growth factor

VEGF

Vascular endothelial growth factor

IGF

Insulin-like growth factor

TGF-β1

Transforming growth factor-beta 1

ECM

Extra cellular matrix

PDGF-B

Platelet-derived growth factor-B

TIMP

Tissue inhibitors of metalloproteinases

BMCs

Bone marrow cells

MSCs

Mesenchymal stem cells

PSCs

Pluripotent stem cells

ESCs

Embryonic stem cells

iPSCs

Induced pluripotent stem cells

CM

Conditioned medium

MFG-E8

Milk fat globule-epidermal growth factor 8

Notes

Acknowledgements

This research was supported by the Bio and Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2017M3A9B4042581) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B2001891).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no competing interests.

Ethical statement

This review article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Dongkyu Kim
    • 1
  • Gun-Sik Cho
    • 1
  • Choongseong Han
    • 1
    • 3
  • Dong-Hyuk Park
    • 2
  • Hee-Kyung Park
    • 3
  • Dong-Hun Woo
    • 1
  • Jong-Hoon Kim
    • 4
    Email author
  1. 1.Laboratory of Stem CellsNEXEL Co., Ltd.SeoulKorea
  2. 2.Department of Neurosurgery, Korea University Medical Center, Anam HospitalKorea University College of MedicineSeoulKorea
  3. 3.Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulKorea
  4. 4.Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Science CampusKorea UniversitySeoulKorea

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