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Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects. The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’. A secondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. In majority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.

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Authors and Affiliations

  1. Restorative Dental Sciences Department, Al-Farabi Colleges, Riyadh, 11313, Saudi Arabia

    Shariq Najeeb

  2. Biomedical Engineering, The University of Western Ontario, London, Ontario, N6A 5B9, Canada

    Zohaib Khurshid

  3. Department of Restorative Dentistry, College of Dentistry, Qassim University, Buraidah, 51452, Saudi Arabia

    Muhammad Atif Saleem Agwan

  4. Department of Oral Microbiology, Dow Dental College, Dow University of Health Sciences, Mission Road, Karachi, 74200, Pakistan

    Shazia Akhbar Ansari

  5. Department of Restorative Dentistry, College of Dentistry, Taibah University, Al-Hezam Street, Al Madinah Al Munawwarah, 41311, Saudi Arabia

    Muhammad Sohail Zafar

  6. Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, 44000, Pakistan

    Muhammad Sohail Zafar

  7. Department of Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Pokfulam, Hong Kong

    Jukka Pekka Matinlinna

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  1. Shariq Najeeb
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Correspondence to Muhammad Sohail Zafar.

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Najeeb, S., Khurshid, Z., Agwan, M.A.S. et al. Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies. Tissue Eng Regen Med 14, 735–742 (2017). https://doi.org/10.1007/s13770-017-0079-5

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