Tissue Engineering and Regenerative Medicine

, Volume 14, Issue 6, pp 699–718 | Cite as

Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering

  • Jia Xian Law
  • Ling Ling Liau
  • Aminuddin Saim
  • Ying Yang
  • Ruszymah Idrus
Review Article


Electrospinning is a simple and versatile technique to fabricate continuous fibers with diameter ranging from micrometers to a few nanometers. To date, the number of polymers that have been electrospun has exceeded 200. In recent years, electrospinning has become one of the most popular scaffold fabrication techniques to prepare nanofiber mesh for tissue engineering applications. Collagen, the most abundant extracellular matrix protein in the human body, has been electrospun to fabricate biomimetic scaffolds that imitate the architecture of native human tissues. As collagen nanofibers are mechanically weak in nature, it is commonly cross-linked or blended with synthetic polymers to improve the mechanical strength without compromising the biological activity. Electrospun collagen nanofiber mesh has high surface area to volume ratio, tunable diameter and porosity, and excellent biological activity to regulate cell function and tissue formation. Due to these advantages, collagen nanofibers have been tested for the regeneration of a myriad of tissues and organs. In this review, we gave an overview of electrospinning, encompassing the history, the instrument settings, the spinning process and the parameters that affect fiber formation, with emphasis given to collagen nanofibers’ fabrication and application, especially the use of collagen nanofibers in skin tissue engineering.


Electrospinning Collagen Skin Tissue engineering Nanofiber Scaffold 


Authors’ contributions

All the authors participate in drafting the article and revising it critically for important intellectual content. All the authors give final approval of the version to be published.

Compliance with ethical standards

Conflict of interest

The authors have no financial conflicts of interest.

Ethical statement

There is no animal experimental carried out for this article.

Supplementary material

13770_2017_75_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 15 kb)
13770_2017_75_MOESM2_ESM.docx (30 kb)
Supplementary material 2 (DOCX 29 kb)


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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Jia Xian Law
    • 1
  • Ling Ling Liau
    • 2
  • Aminuddin Saim
    • 3
  • Ying Yang
    • 4
  • Ruszymah Idrus
    • 2
  1. 1.Tissue Engineering CentreUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia
  2. 2.Department of Physiology, Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia
  3. 3.Ear, Nose and Throat Consultant ClinicAmpang Puteri Specialist HospitalAmpangMalaysia
  4. 4.Institute for Science and Technology in Medicine, School of MedicineKeele UniversityStoke-on-TrentUK

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