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Use of nonhuman primates for the development of bioengineered female reproductive organs

  • Feature Article
  • Regenerative Medicine
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Nonhuman primates (NHPs) have been widely used in reproductive biology, neuroscience, and drug development since a number of primate species are phylogenetically close to humans. In this review, we summarize the use of NHPs for nonclinical application in the reproductive system disorders including the loss or failure of an organ or tissue. Causes of infertility include congenital aplasia and acquired disorders of the reproductive organs. In addition, anti-cancer treatments can deplete ovarian follicles, leading to premature ovarian failure, infertility and long-term health risks. Along with a limited supply of human reproductive organs, anatomic/physiologic similarities to humans support the need for NHP models (New-World monkeys such as the common marmoset and Old-World monkeys such as cynomolgus and rhesus monkeys) to promote the advances in female infertility studies. For maintaining and executing animal studies using NHP, special protocols including animal care, anesthetic protocol, surgical technique, and immunosuppressive protocol are necessary. With a growing interest in the potential therapies such as endometrial tissue engineering, and ovary/follicle cryopreservation and grafting in Korea, this review can be useful in selecting appropriate animal models and can bridge between nonclinical studies and clinical applications by providing detailed information on the use of NHPs in the field of reproductive organ disorders.

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Authors and Affiliations

  1. Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea

    Jun-Won Yun, Jae Hun Ahn & Byeong-Cheol Kang

  2. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea

    Yoon Young Kim & Seung-Yup Ku

  3. Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea

    Jae Hun Ahn & Byeong-Cheol Kang

  4. Designed Animal Research Center, Institute of GreenBio Science Technology, Seoul National University, Pyeongchang, Korea

    Byeong-Cheol Kang

  5. Biomedical Center for Animal Resource and Development, N-BIO, Seoul National University, Seoul, Korea

    Byeong-Cheol Kang

  6. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Byeong-Cheol Kang

  7. Graduate School of Translational Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea

    Seung-Yup Ku

Authors
  1. Jun-Won Yun
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  2. Yoon Young Kim
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  3. Jae Hun Ahn
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  4. Byeong-Cheol Kang
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  5. Seung-Yup Ku
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Corresponding authors

Correspondence to Byeong-Cheol Kang or Seung-Yup Ku.

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Yun, JW., Kim, Y.Y., Ahn, J.H. et al. Use of nonhuman primates for the development of bioengineered female reproductive organs. Tissue Eng Regen Med 13, 323–334 (2016). https://doi.org/10.1007/s13770-016-9091-4

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  • DOI: https://doi.org/10.1007/s13770-016-9091-4

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