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Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation

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Abstract

Excessive accumulation of reactive oxygen species (ROS) during oxidative stress accelerates the skin aging process. ROS stimulate inflammatory processes in the skin, leading to activation of matrix metalloprotease-1 (MMP-1). Silent information regulator 1 (SIRT1) controls a broad range of cellular functions including the expression of MMP-1. Omega-7 fatty acids such as palmitoleic acid have many beneficial effects on health, including improvement in cardiovascular risk factors and increased insulin sensitivity. However, the effectiveness of omega-7 fatty acids (herein referred to as omega-7) related to skin aging, characterized by the degradation of collagen and loss of elasticity, remains unclear. We here investigated the effects of palmitoleic acid, a representative omega-7, on collagen regeneration through its ability to activate SIRT1 and inhibit MMP-1 in the presence of hydrogen peroxide (H2O2)-induced oxidative stress in human HaCaT cells. SIRT1 activation by omega-7 decreased signaling levels of nuclear transcription factor kappa B (NF-κB) and inflammatory cytokines. However, inhibition of SIRT1 by sirtinol counteracted the advantage effects of omega-7 in H2O2-treated HaCaT cells. In addition, omega-7 significantly counteracted the decrease in collagen abundance and loss of elasticity induced by H2O2. Consistent with this observation, omega-7 significantly decreased H2O2-induced upregulation of MMP-1 in HaCaT cells. Together, these studies suggest the potential efficacy of SIRT1 in collagen regeneration and indicate that omega-7 is a possible functional food to improve skin health for the prevention of aging.

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Acknowledgments

This research was supported by Vitech Co., Ltd.

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Authors and Affiliations

  1. Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University, Iksan, Jeonbuk, 54596, Republic of Korea

    In-Bong Song, Hyejung Gu, Hye-Ju Han & Jungkee Kwon

  2. R&D Team, Food & Supplement Health Claims, Vitech, Jeonju, Jeonbuk, Republic of Korea

    Na-Young Lee, Ji-Yun Cha & Yeon-Kyong Son

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  1. In-Bong Song
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  2. Hyejung Gu
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  3. Hye-Ju Han
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  7. Jungkee Kwon
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Correspondence to Jungkee Kwon.

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Song, IB., Gu, H., Han, HJ. et al. Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation. Appl Biol Chem 61, 433–439 (2018). https://doi.org/10.1007/s13765-018-0377-1

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