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Food, cosmetic and biological applications of characterized DOPA-melanin from Vibrio alginolyticus strain BTKKS3

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Abstract

Melanins are one of the most common pigments produced in nature and distributed throughout the biological kingdom. Vibrio alginolyticus strain BTKKS3 produced DOPA-melanin was used in the study. BTKKS3 melanin inhibited biofilm formation by pathogenic bacteria and effectively decreased the activity of four inflammatory enzymes tested viz. cyclooxygenase, lipoxygenase, myeloperoxidase and nitric oxide synthase. Melanin proved to be less cytotoxic to mouse fibroblast cells with an IC50 value of 134.98 μg/mL. The sun protection factor value of commercial sunscreens was enhanced by 3.42 units by DOPA-melanin.

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  1. Department of Biotechnology, Cochin University of Science and Technology, Kalamassery, Cochin, Kerala, 682022, India

    Noble K. Kurian & Sarita G. Bhat

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  1. Noble K. Kurian
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  2. Sarita G. Bhat
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Correspondence to Sarita G. Bhat.

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Kurian, N.K., Bhat, S.G. Food, cosmetic and biological applications of characterized DOPA-melanin from Vibrio alginolyticus strain BTKKS3. Appl Biol Chem 61, 163–171 (2018). https://doi.org/10.1007/s13765-018-0343-y

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