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Screening of various sources of phytochemicals for neuroprotective activity against oxygen-glucose deprivation in vitro

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Abstract

Neuroprotective activities of 176 phytochemicals were investigated against oxygen-glucose deprivation in vitro using primary cortical neuron culture. Diterpenes (taxol and taxol C) were the most potent neuroprotective compounds. EC50 of taxol and taxol C were 0.402 and 0.452 μM, respectively. This result supports the use of an in vitro model as initial screening for neuroprotective candidates, which warrants further testing in animal models.

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References

  • Andrabi SA, Spina MG, Lorenz P, Ebmeyer U, Wolf G, and Horn TFW (2004) Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res 1017, 98–107.

    Article  CAS  Google Scholar 

  • Bei W, Zang L, Guo J, Peng W, Xu A, Good DA et al. (2009) Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves. J Ethnopharmacol 126, 134–142.

    Article  CAS  Google Scholar 

  • Bora KS and Sharma A (2010) Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. J Ethnopharmacol 129, 403–409.

    Article  Google Scholar 

  • Chandrasekaran K, Mehrabian Z, Spimmewyn B, Drieu K, and Fiskum G (2001) Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia. Brain Res 922, 282–292.

    Article  CAS  Google Scholar 

  • Chang H-J, Kim HJ, and Chun HS (2007) Quatitative structure-activity relationship (QSAR) for neuroprotective activity of terpenoids. Life Sci 80, 835–841.

    Article  CAS  Google Scholar 

  • Chao X, Zhou J, Chen T, Liu W, Dong W, Qu Y et al. (2010) Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Brain Res 1363, 206–211.

    Article  CAS  Google Scholar 

  • Choi CW, Choi YH, Cha M-R, Kim YS, Yon GH, Hong KS et al. (2011) In vitro BACE-1 inhibitory activity of resveratrol oligomers from the seed extract of Paeonia lactiflora. Planta Med 77, 346–376.

    Article  Google Scholar 

  • Choi YH, Yoo DS, Cha M-R, Choi CW, Kim YS, Choi SU et al. (2010) Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells. J Nat Prod 73, 1863–1867.

    Article  CAS  Google Scholar 

  • Ebrahimi A and Schluesener H (2012) Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls. Ageing Res Rev 11, 329–345.

    Article  CAS  Google Scholar 

  • Jensen FE, Gardner GJ, Gallop PM, Aizenman E, and Rosenberg PA (1994) The putative essential nutrient pyrroloquinoline quinine is neuroprotective in a rodent model of hypoxic/ischemic brain injury. Neurosci 62, 399–406.

    Article  CAS  Google Scholar 

  • Jiang E-p, Li H, Chen J-g, and Yang S-j (2011) Protective by the gross saponins of Tribulus terrestris against cerebral ischemic injury in rats involves the NF-κB pathway. Acta Pharmaceutica Sinica B 1, 21–26.

    Article  CAS  Google Scholar 

  • Kim J-M, Lee J-C, Chang N, Chun HS, and Kim W-K (2006) S-Allyl-Lcysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase. Free Radic Res 40, 827–835.

    Article  CAS  Google Scholar 

  • Li H, Yan Z, Zhu J, Yang J, and He J (2011) Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats. Neuropharmacol 60, 252–258.

    Article  CAS  Google Scholar 

  • Liang H, Liu P, Wang Y, Song S, and Ji A (2011) Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. Phytomed 18, 811–818.

    Article  CAS  Google Scholar 

  • Maher P, Salgado KF, Zivin JA, and Lapchak PA (2007) A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res 1173, 117–125.

    Article  CAS  Google Scholar 

  • Malik ZA, Singh M, and Sharma PL (2011) Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. J Ethnopharmacol 133, 729–734.

    Article  Google Scholar 

  • Sayeed I and Stein DG (2009) Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. Prog Brain Res 175, 219–237.

    Article  CAS  Google Scholar 

  • Shaheen AA and Chan (1996) Influence of verapamil on the efficacy of vitamin E in preventing the ischemia-reperfusion biochemical dearrangement in cerebral cortex of rats. Arzneimittel-Forschung/Drug Res 46, 7670–7673.

    Google Scholar 

  • Singer CA, Figueroa-Masot XA, Batchelor RH, Dorsa DM (1999) The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 19, 2455–2463.

    CAS  Google Scholar 

  • Son D, Lee P, Lee J, Lee S, Choi SY, Lee J-W et al. (2007) Neuroprotective effect of scopoletin from Angelica dahurica on oxygen and glucose deprivation-exposed rat organotypic hippocampal slice culture. Food Sci Biotechnol 16, 632–635.

    CAS  Google Scholar 

  • Suzuki S, Brown CM, and Wise PM (2009) Neuroprotective effects of estrogens following ischemic stroke. Front Neuroendocrinol 30, 201–211.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Food Safety Research Group, Korea Food Research Institute, 516, Backhyun-dong, Bundang-gu, Sungnam, Gyonggi-do, 463-746, Republic of Korea

    Hyun-Joo Chang

  2. Division of Drug Discovery Research, Korea Research Institute of Chemical Technology 141 Gajeongro, Yuseong, Daejeon, 305-600, Republic of Korea

    Young Sup Kim & Shi Yong Ryu

  3. School of Food Science and Technology, Chung-Ang University, Naeri 721, Ansung, Kyounggi, 456-756, Republic of Korea

    Hyang Sook Chun

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  1. Hyun-Joo Chang
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  2. Young Sup Kim
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  4. Hyang Sook Chun
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Correspondence to Hyang Sook Chun.

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Chang, HJ., Kim, Y.S., Ryu, S.Y. et al. Screening of various sources of phytochemicals for neuroprotective activity against oxygen-glucose deprivation in vitro . J Korean Soc Appl Biol Chem 56, 451–455 (2013). https://doi.org/10.1007/s13765-013-3108-7

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  • DOI: https://doi.org/10.1007/s13765-013-3108-7

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