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Effect of soy phosphatidylserine supplemented diet on skin wrinkle and moisture in Vivo and clinical trial

Journal of the Korean Society for Applied Biological Chemistry volume 56, pages 227–235 (2013)Cite this article

Abstract

Effect of supplementation of phosphatidylserine (PS), enzymatically synthesized from soy lecithin, on skin moisture and wrinkle in animal and human was investigated. Skin moisture content of hairless mice was significantly decreased and skin thickness and wrinkle were significantly increased by UV irradiation, whereas PS-supplemented groups showed reduced wrinkle depth and much less wrinkle area unlike UV control (UV/Con) group. The collagen content in PS-supplemented groups increased compared with that in UV/Con group. A placebo-controlled double-blind intake study of soft capsules containing PS (300 mg/day) was performed on 63 subjects who had normal healthy skin for 12 weeks. Dermatologist’s visual assessment and image analysis of replicas showed that wrinkle near eye was improved by PSsupplementation. Upon measurement of moisture content in the skin, PS supplementation increased the moisture content in the skin. These findings showed that PS supplementation was effective in moisturizing and improving wrinkle of the skin in both animal and human; thus, PS could be used as an effective skin food ingredient.

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Authors and Affiliations

  1. Korea Food Research Institute, Seongnam, Gyeonggi, 463-746, Republic of Korea

    Hee-Don Choi, Sang-Hoon Lee & Yun-Sook Kim

  2. Doosan Glonet BG Biotech Division, Suwon, Gyeonggi, 443-270, Republic of Korea

    Jeong-Jun Han & Guk-Hoon Chung

  3. Korea Food Research Institute, World Institute of Kimchi, Gwangju, 503-360, Republic of Korea

    Ji-Hee Yang

  4. College of Oriental Medicine, Kyung Hee University, Seoul, 446-701, Republic of Korea

    Dae-Hyun Hahm

Authors
  1. Hee-Don Choi
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  2. Jeong-Jun Han
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  3. Ji-Hee Yang
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  4. Sang-Hoon Lee
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  5. Yun-Sook Kim
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  6. Guk-Hoon Chung
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  7. Dae-Hyun Hahm
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Correspondence to Hee-Don Choi or Jeong-Jun Han.

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Choi, HD., Han, JJ., Yang, JH. et al. Effect of soy phosphatidylserine supplemented diet on skin wrinkle and moisture in Vivo and clinical trial. J Korean Soc Appl Biol Chem 56, 227–235 (2013). https://doi.org/10.1007/s13765-013-3012-1

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  • DOI: https://doi.org/10.1007/s13765-013-3012-1

Keywords

  • anti-wrinkle
  • moisturizing effect
  • phosphatidylserine
  • skin barrier function
  • supplementation