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Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin

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Abstract

Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC50 values of 21.02 and 10.28 μM, respectively.

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Authors and Affiliations

  1. Graduate School of Biotechnology, Institute of Life Sciences & Resources, Kyung Hee University, Yongin, 446-701, Republic of Korea

    Sabina Shrestha, Dae-Young Lee, Ji-Hae Park, Jin-Gyeong Cho & Nam-In Baek

  2. Department of Functional Crop, National Institute of Crop Science, Rural Development Administration, Milyang, 527-830, Republic of Korea

    Woo-Duck Seo

  3. R&D Center, Green Flower Cosmetics Co., Suwon, 443-813, Republic of Korea

    Hee Cheol Kang

  4. Ildong Research Laboratories, Ildong Pharmaceutical Co., Ltd., Yongin, 445-170, Republic of Korea

    Yong-Jin Jeon & Seung-Woo Yeon

  5. Skin Biotechnology Center, Kyung Hee University, Gyeonggi Biocenter, Suwon-Si, Gyeonggi-Do, 443-766, Republic of Korea

    Myun-Ho Bang

Authors
  1. Sabina Shrestha
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  2. Dae-Young Lee
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  3. Ji-Hae Park
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  4. Jin-Gyeong Cho
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  5. Woo-Duck Seo
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  6. Hee Cheol Kang
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  7. Yong-Jin Jeon
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  8. Seung-Woo Yeon
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  9. Myun-Ho Bang
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  10. Nam-In Baek
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Correspondence to Nam-In Baek.

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Shrestha, S., Lee, DY., Park, JH. et al. Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin. J Korean Soc Appl Biol Chem 55, 689–693 (2012). https://doi.org/10.1007/s13765-012-2133-2

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  • DOI: https://doi.org/10.1007/s13765-012-2133-2

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