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Influence of metal ions concentration in drinking water in the development of ulcerative colitis

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Abstract

Ulcerative colitis (UC) imposes high economic burden to the health systems. However, the risk factors for development of the disease are still remained unknown. Exposure to heavy metals may be associated with occurrence of UC. The aim of this study was to evaluate the relationship between the concentration of metal(loid)s including Pb, As, Ni, Cu, Zn, Fe, and Se in drinking water with incidence of UC. To do this, 35 biopsy samples were each taken from patients and healthy subjects along with the same number of samples of their drinking water. The furnace atomic absorption spectrophotometry was used for sample analysis. Our results showed that exposure to Pb, As, Cu, and Fe was associated with occurrence of UC (ORs > 1; P < 0.05); meanwhile, the concentrations of Zn and Ni were higher in healthy subject biopsies than UC patients (ORs < 1; P < 0.05). Also, the mean concentration of Pb in the drinking water samples (0.12 ± 0.07 mg/L) was higher than the permissible limit of the Institute of Standards and Industrial Research of Iran (ISIRI). The results showed that by increasing Pb in drinking water, Zn concentration in the intestinal tissues of patients was decreased (P = 0.005). However, the concentration of Pb, As, Cu, and Fe in UC patients may affect the exacerbation of the disease, though Zn may potentially reduce the risk of this disease. In conclusion, our findings demonstrated that exposure to the metal ions through drinking water can affect the body’s heavy metal content, which may be act as preventing or developing factors for UC.

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Acknowledgements

We are grateful to the financial support (Grant No. 2583) of the research deputy of Shahrekord University of Medical Sciences and the collaboration of both Hajar Hospital and the Center for Cohort Studies.

Funding

This work was supported by research deputy of Shahrekord University of Medical Sciences [Grant No. 2583].

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Authors and Affiliations

  1. Department of Environmental Health Engineering, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

    F. Bagherzadeh, M. Sadeghi, A. Fadaei, S. Forouzandeh, S. Hemati & F. Mohammadi-Moghadam

  2. Department of Gastroenterology and Hepatology, Shahrekord University of Medical Sciences, Shahrkord, Iran

    M. Karami Horestani & R. Bahreini

  3. Department of Epidemiology, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

    A. Ahmadi

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  1. F. Bagherzadeh
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Contributions

FMM: performed the experiments and writing the manuscript. RB and MK: Taking the biopsies and complete the questionnaire. FB and SH: study design and writing the manuscript, as well as, taking the water samples. AA: Data analysis. SF: contributed to perform the experiments and heavy metals measurement. MS and AF: editing the manuscript and involved in criticism of the manuscript. All authors have approved the final version of the manuscript.

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Correspondence to F. Mohammadi-Moghadam.

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Editorial responsibility: Samareh Mirkia.

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Bagherzadeh, F., Karami Horestani, M., Sadeghi, M. et al. Influence of metal ions concentration in drinking water in the development of ulcerative colitis. Int. J. Environ. Sci. Technol. 19, 3539–3546 (2022). https://doi.org/10.1007/s13762-021-03498-6

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  • DOI: https://doi.org/10.1007/s13762-021-03498-6

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