Slow release formulation of herbicide metazachlor based on high molecular weight poly(lactic acid) submicro and microparticles

Abstract

Frequently used pre-emergent herbicide metazachlor was encapsulated into high molecular weight poly(lactic acid) particles, and its subsequent release and the effectivity of such formulations were investigated. Two sets of polymeric micro- and submicro particles, both with the theoretical metazachlor loading of 20%, 30%, and 40%, were prepared and characterized. Loading efficiency reached 80% for both types of particles. Release profiles were tested in vitro for the individual particle variants and were shown to have a bimodal profile with the initial fast burst release and much slower second phase. Finally, selected formulations were tested in vivo against target plants (field poppy and barnyard grass) and non-targets plants (mustard and rapeseed) and showed improved inhibition of target plants (about 30% higher for barnyard grass) and at the same time lower inhibition of non-target plants (rapeseed) in comparison with the identical dose of metazachlor alone.

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Acknowledgements

Financial support from Tomas Bata University in Zlín, Internal Grant Agencies (Project IGA/FT/2018/009 and IGA/FT/2019/011) was gratefully acknowledged.

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Correspondence to M. Koutný.

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Editorial responsibility: M. Abbaspour.

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Salač, J., Šopík, T., Stloukal, P. et al. Slow release formulation of herbicide metazachlor based on high molecular weight poly(lactic acid) submicro and microparticles. Int. J. Environ. Sci. Technol. 16, 6135–6144 (2019). https://doi.org/10.1007/s13762-019-02222-9

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Keywords

  • Poly(lactic acid)
  • Metazachlor
  • Herbicide
  • Controlled release
  • Microparticles