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Rapid eye movement sleep behavior disorder is associated with decreased quality of life and stigma in people with Parkinson’s disease

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Abstract

Background

Individuals with Parkinson’s disease (PD) may present with rapid eye movement sleep behavior disorder (RBD). We therefore investigated the association between RBD and quality of life (QOL) in people with PD.

Methods

Individuals with PD and a Mini–Mental State Examination score ≥ 24 were divided into two groups using the RBD screening questionnaire (RBDSQ): those with an RBDSQ score ≥ 5 were assigned to the “probable RBD” (pRBD) group, and those with a score < 5 to the “non-pRBD” group. Participants were then evaluated for motor symptoms (Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III and modified Hoehn and Yahr Scale), cognitive functions (Montreal Cognitive Assessment and Frontal Assessment Battery [FAB]), anhedonia (Snaith–Hamilton Pleasure Scale), and QOL (Parkinson’s Disease Questionnaire [PDQ]-39 total and subscores for mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort). Each measure was compared between the two groups (Mann–Whitney U test/χ2 test). Multiple regression analyses were performed to identify factors contributing to the total score and the subscore of the stigma domain of the PDQ-39.

Results

Ninety-three individuals with PD were recruited (mean ± standard deviation age, 67.0 ± 10.6 years). The pRBD group exhibited a longer disease duration (P = 0.006), worse FAB (P = 0.015) and PDQ-39 total (P = 0.032) scores. RBDSQ scores correlated with higher scores in the PDQ-39 stigma domain (B = 2.44, P = 0.033).

Conclusion

RBD is associated with worse QOL and stigma in people with PD. The RBDSQ is a useful tool for the prediction of such disturbances in QOL.

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Data availability

The authors confirm that the data supporting the findings of this study are available within the supplementary materials.

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Acknowledgements

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Authors and Affiliations

  1. Department of Neurology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan

    Masakazu Ozawa, Hidetomo Murakami, Tomotaka Shiraishi, Tadashi Umehara & Yasuyuki Iguchi

  2. Department of Neurology, The Jikei University Katsushika Medical Center, 6-41-2 Aoto, Katsushika-Ku, Tokyo, 125-8506, Japan

    Shusaku Omoto

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Contributions

MO and HM: contributed to the study conception and design. Data collection was performed by all authors. Data analysis was performed by MO and HM. The first draft of the manuscript was written by MO. All authors commented on previous versions of the manuscript and approved the final manuscript.

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Correspondence to Masakazu Ozawa.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Ethical approval

This study was approved by the Ethics Committee of Jikei University (approval number: 27–315 [8200]) and performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants.

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Ozawa, M., Murakami, H., Shiraishi, T. et al. Rapid eye movement sleep behavior disorder is associated with decreased quality of life and stigma in people with Parkinson’s disease. Acta Neurol Belg 123, 1073–1079 (2023). https://doi.org/10.1007/s13760-023-02213-1

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  • DOI: https://doi.org/10.1007/s13760-023-02213-1

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