Abstract
Background
Hypoxic ischemic encephalopathy (HIE) has different neurological outcomes.
Aim
We wanted to see if there was any developmental delay in neonates with hypoxia ischemic encephalopathy who were given therapeutic hypothermia.
Study design
Retrospective cohort study.
Methods
The Denver developmental screening test II (DDST-II) was performed to newborns who had been applied to therapeutic hypothermia.
Results
There were 69 male and 36 female newborns. The mean 1-min and 5-min Apgar scores were 4.72 ± 2.51 and 7.03 ± 2.017, respectively. The mean pH and mean base excess were 6.92 ± 0.1 and −18.05 ± 5.72, respectively. The most common risk factors were meconium staining (17.1%). There were 67 patients with Stage I, 20 with Stage II, and 18 with Stage III. Diffusion restriction was seen in 13 patients. 28 patients had seizures. In aEEG, 12 patients had burst suppression. Three (2.9%) infants died during hospitalization. 19 patients missed follow-up appointments. Thirteen patients had abnormal development according to DDST-II. Seven patients had gross motor function delays and were diagnosed with cerebral palsy. Three had language skill delays, but two of them had speech disorders after two years of age. Two had delayed milestones. Two had delays in fine motor skills but did not have any sequels after two years of age.
A significant difference was found between seizures and the severity of Sarnat stage, intubation in the delivery room with developmental delay. Apgar scores were significantly lower in patients with CP.
Conclusion
We should closely follow-up neonates who had low Apgar scores, seizures, a high Sarnat stage, were intubated in the delivery room.
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SY, EY made substantial contributions to the conception or design of the work; SY, TBK, YB, AE made the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; SY, SA, AE drafted the work or revised it critically for important intellectual content; SY, TBK, SA, EY, YB, AE approved the version to be published; and all authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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Yimenicioglu, S., Kaya, T.B., Yıldırım, E. et al. The factors affecting neurodevelopmental outcomes in HIE. Acta Neurol Belg 123, 1903–1909 (2023). https://doi.org/10.1007/s13760-022-02126-5
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DOI: https://doi.org/10.1007/s13760-022-02126-5