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Brain MRI abnormalities in a child with spinal muscular atrophy type II

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References

  1. Verhaart IE, Robertson A, Leary R, McMacken G, König K, Kirschner J, Jones CC, Cook SF, Lochmüller H (2017) A multi-source approach to determine SMA incidence and research ready population. J Neurol 264(7):1465–1473

    Article  Google Scholar 

  2. Trabacca A, Lucarelli E, Pacifico R, Vespino T, Di Liddo A, Losito L (2020) The ICF-CY as a framework for the management of spinal muscular atrophy in the era of gene therapy: a proof-of-concept study. Eur J Phys Rehabil Med 56(2):243–251

  3. Lefebvre S, Bürglen L, Reboullet S, Clermont O, Burlet P, Viollet L, Benichou B, Cruaud C, Millasseau P, Zeviani M (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80(1):155–165

    Article  CAS  Google Scholar 

  4. Angelini C, Pinzan E (2019) Advances in imaging of brain abnormalities in neuromuscular disease. Ther Adv Neurol Disord 12:1756286419845567

    PubMed  PubMed Central  Google Scholar 

  5. Polido GJ, Barbosa AF, Morimoto CH, Caromano FA, Favero FM, Zanoteli E, Reed UC, Voos MC (2017) Matching pairs difficulty in children with spinal muscular atrophy type I. Neuromuscul Disord 27(5):419–427

    Article  Google Scholar 

  6. Yeo CJJ, Darras BT (2020) Overturning the paradigm of spinal muscular atrophy as just a motor neuron disease. Pediatr Neurol 109:12–19

  7. Harding BN, Kariya S, Monani UR, Chung WK, Benton M, Yum SW, Tennekoon G, Finkel RS (2015) Spectrum of neuropathophysiology in spinal muscular atrophy type I. J Neuropathol Exp Neurol 74(1):15–24

    Article  CAS  Google Scholar 

  8. Mendonça RH, Rocha AJ, Lozano-Arango A, Diaz AB, Castiglioni C, Silva AM, Reed UC, Kulikowski L, Paramonov I, Cuscó I (2019) Severe brain involvement in 5q spinal muscular atrophy type 0. Ann Neurol 86(3):458–462

    Article  Google Scholar 

  9. Somers E, Lees RD, Hoban K, Sleigh JN, Zhou H, Muntoni F, Talbot K, Gillingwater TH, Parson SH (2016) Vascular defects and spinal cord hypoxia in spinal muscular atrophy. Ann Neurol 79(2):217–230

    Article  CAS  Google Scholar 

  10. Ito Y, Kumada S, Uchiyama A, Saito K, Osawa M, Yagishita A, Kurata K, Hayashi M (2004) Thalamic lesions in a long-surviving child with spinal muscular atrophy type I: MRI and EEG findings. Brain Develop 26(1):53–56

    Article  Google Scholar 

  11. Stam M, Haakma W, Kuster L, Froeling M, Philippens ME, Bos C, Leemans A, Otto LA, van den Berg LH, Hendrikse J (2019) Magnetic resonance imaging of the cervical spinal cord in spinal muscular atrophy. NeuroImage Clin 24:102002

    Article  Google Scholar 

  12. Truwit CL, Barkovich AJ (1990) Pathogenesis of intracranial lipoma: an MR study in 42 patients. AJR Am J Roentgenol 155(4):855–864

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank the parents of our patient for their cooperation and support of this study. This study was supported by Italian Ministry of Health, Grant number R.C. 2018-2020.

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Correspondence to Antonio Trabacca.

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Losito, L., Gennaro, L., Lucarelli, E. et al. Brain MRI abnormalities in a child with spinal muscular atrophy type II. Acta Neurol Belg 121, 1883–1885 (2021). https://doi.org/10.1007/s13760-020-01524-x

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