Kennedy’s disease: an under-recognized motor neuron disorder

Abstract

Kennedy’s disease or spinal bulbar muscular atrophy is a rare, inherited and slowly progressive multisystem disease mostly manifesting with a motor neuron disease phenotype leading to disability. The slow progression, partial androgen insensitivity, electrophysiological evidence of sensory neuronopathy, and relatively spared central nervous system pathways help differentiate it from amyotrophic lateral sclerosis. To date, there is no treatment or cure with clinical care mainly focused on accurate diagnosis, symptom management, patient education, and genetic counselling.

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EM: drafted the manuscript. AM: revised the manuscript for intellectual content. JS: revised the manuscript for intellectual content.

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Correspondence to Achraf Makki.

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Dr. Elia Malek reports no disclosures. Dr. Achraf Makki reports no disclosures. Dr. Johnny Salameh reports no disclosures.

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Malek, E.G., Salameh, J.S. & Makki, A. Kennedy’s disease: an under-recognized motor neuron disorder. Acta Neurol Belg (2020). https://doi.org/10.1007/s13760-020-01472-6

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Keywords

  • Kennedy’s disease
  • Spinal bulbar muscular atrophy
  • Motor neuron disease