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Relationship between migraine headache and hematological parameters

Abstract

Although migraine is a neurological disorder known for its long, physiopathology remains unclear. The aim of this study was to investigate the levels of hematological parameters and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and neutrophil/monocyte ratio (NMR) used as inflammatory markers in patients diagnosed with migraine. This retrospective study was performed with 250 patients and 215 healthy volunteers who were followed up in the neurology outpatient clinic with the diagnosis of migraine. Hematological parameters, C-reactive protein (CRP), NLR, PLR, LMR, NMR ratios were compared in the patient and control groups. Patients with migraine were grouped according to loss of function, the severity of pain and aura. 20.8% of patients in the mean age of 36.37 ± 8.683 had migraine with aura. We found that NMR values in migraine with aura (MWA) were significantly higher than in the control group. CRP, PLR and NMR values in migraine without aura (MWOA) were significantly higher than in the control group. Mean platelet volume (MPV) and platelet values were higher in patients with MWA and MWOA compared to the control group but did not show a statistically significant difference. We believe that these results support systemic inflammation in patients with migraine and the presence of a continuous inflammatory process even in periods without attacks. More comprehensive studies are needed to clarify the underlying pathophysiology that may guide the follow-up and treatment of the disease.

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GS collected and integrated the data. GS conceived and designed the study, analyzed the data, wrote and reviewed the paper, and were responsible for statistical analysis. Author approved the final version of this paper for publication.

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Correspondence to Gulhan Sarıcam.

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The authors declare that they have no conflict of interest.

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All procedures performed in this study were in accordance with the ethical standards of the Medical Ethical Committee at the Ankara Numune Training and Research Hospital (approval no: E-19-2622) and the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sarıcam, G. Relationship between migraine headache and hematological parameters. Acta Neurol Belg 121, 899–905 (2021). https://doi.org/10.1007/s13760-020-01362-x

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  • DOI: https://doi.org/10.1007/s13760-020-01362-x

Keywords

  • Migraine
  • Inflammation
  • Neutrophil/lymphocyte ratio