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Bright light therapy with a head-mounted device for anxiety, depression, sleepiness and fatigue in patients with Parkinson’s disease


The beneficial effects of bright light therapy (BLT) on the disabling non-motor symptoms of Parkinson’s disease (PD) remain uncertain. The objective of this study was to investigate if daily BLT, with a head-mounted device (Luminette®), has a beneficial effect on depression, anxiety, daytime sleepiness and fatigue in patients with PD. In this double-blind, placebo-controlled study, 16 patients with PD were randomized to receive either 1 month of BLT or 1 month of placebo therapy, separated by a 2-week washout period, in a crossover fashion. Patients completed questionnaires for the Hospital Anxiety and Depression Scale (HADS), the Epworth Sleepiness Scale (ESS) and the Fatigue Impact Scale (FIS) before and after each treatment period. The primary outcome measures were changed from baseline in scores between treatment groups. No significant changes were observed in the HADS anxiety scores and FIS scores after BLT and after placebo. The ESS scores decreased non-significantly only after BLT. A post hoc analysis of patients who had baseline ESS scores > 11 revealed a significantly greater decrease in ESS scores after BLT than after placebo. Future studies investigating the effect of BLT on sleepiness could focus specifically on patients with high ESS scores.

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We would like to thank Doctors Marie-Céline Duray and Michel Dupuis from the Neurology Department at Clinique Saint-Pierre Ottignies, Belgium for their help in recruiting patients. We would like to thank Lucimed SA, Villers-le-Bouillet, Belgium for providing the Luminette® light therapy devices.


No funding was received for this study.

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Correspondence to Frédéric Evrard.

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Conflict of interest

Lucimed SA, Villers-le-Bouillet, Belgium provided the active and placebo light therapy devices (Luminette®) but did not fund the study nor were they involved in any aspect of the study management (design, collection of data, data analysis or preparation of the manuscript). There were no conflicts of interest with this donation. Neither the authors nor the institution conducting the study have a conflict of interest with Lucimed. Patients were aware of the brand name on the product.

Ethical approval

The study protocol, questionnaires and consent forms were approved by the institutional ethics committee of Clinique Saint Pierre, Ottignies, Belgium and the study was performed in accordance with the ethical standards of this committee and those of the 1964 Declaration of Helsinki [34] and its amendments.

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All participants gave written informed consent prior to study start.

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Raymackers, JM., Andrade, M., Baey, E. et al. Bright light therapy with a head-mounted device for anxiety, depression, sleepiness and fatigue in patients with Parkinson’s disease. Acta Neurol Belg 119, 607–613 (2019).

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  • Parkinson’s disease
  • Sleepiness
  • Phototherapy
  • Depression
  • Anxiety