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Another brick in the wall: is hexane neuropathy a ‘nodo-paranodopathy’?

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Abstract

n-Hexane gives cause to one of the most common toxic polyneuropathies seen in poorly ventilated factories. It is a sensory-motor polyneuropathy ending up with axonal degeneration. Nerve biopsy reveals paranodal axonal swelling and secondary myelin retraction in early stages. Myelin retraction imitates demyelination causing focal conduction block and failure before axonal degeneration emerges. This brings to mind the new category of nodo-paranodopathy described first for anti-ganglioside antibody-mediated neuropathies, which can be proved by electrophysiological re-evaluations. We, herein, discuss the clinical and electrophysiological follow-up of three patients with n-hexane neuropathy and remark overlaps with new concept nodo-paranodopathy.

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Authors and Affiliations

  1. Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic, and Neurosurgical Diseases, University of Health Sciences, Zuhuratbaba mah. Dr. Tevfik Sağlam cad. No: 25/2, 34147, Bakırköy, Istanbul, Turkey

    Sezin Alpaydin Baslo, Oya Ozturk, Cengiz Dayan & Dilek Atakli

  2. Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Mehmet Baris Baslo

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  1. Sezin Alpaydin Baslo
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  2. Oya Ozturk
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  4. Dilek Atakli
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  5. Mehmet Baris Baslo
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Correspondence to Sezin Alpaydin Baslo.

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Alpaydin Baslo, S., Ozturk, O., Dayan, C. et al. Another brick in the wall: is hexane neuropathy a ‘nodo-paranodopathy’?. Acta Neurol Belg 121, 373–378 (2021). https://doi.org/10.1007/s13760-019-01137-z

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  • DOI: https://doi.org/10.1007/s13760-019-01137-z

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