Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis
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The relationship between Parkinson’s disease (PD) and risk of hip fracture yielded inconsistent results. Therefore, we conducted the present systematic review and meta-analysis of published observational studies to assess the association between PD and risk of hip fracture. PubMed, ISI, EMBASE, and Cochrane databases were searched systematically to identify studies assessing the relationship between PD and the risk of hip fracture up to July 01, 2017. In addition, to find related articles, the reference section of retrieved articles was checked. Random-effects model was used for calculation of pooled hazard ratio (HR) and 95% confidence intervals (CI). Thirteen independent studies containing 564,947 participants were included in the meta-analysis. The overall results of included studies showed PD to be associated with the risk of hip fracture (HRoverall = 3.13, 95% CI 2.53–3.87) in women 3.11 (2.51–3.86) and men 2.60 (2.19–3.09). Our meta-analysis showed the direct association between PD and the risk of hip fracture in both men and women. However, due to the limitations of this study, further well-designed studies are required to confirm our findings.
KeywordsParkinson’s disease Hip fracture Meta-analysis Risk factor
Compliance with ethical standards
Conflict of interest
Ali Hosseinzadeh, Malahat Khalili, Behnaz Sedighi, Sohrab Iranpour, and Ali Akbar Haghdoost declare that they have no conflict of interest. The authors alone are responsible for the content and writing of this paper.
This article does not contain any studies with human participants or animals performed by any of the authors.
For this type of study formal consent is not required.
- 1.Launer L, Berger K, Breteler M, Dartigues J, Baldereschi M, Fratiglioni L, Lobo A, Martinez-Lage J, Trenkwalder C, Hofman A (2000) Prevalence of Parkinson’s disease in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54(11 Suppl 5):S21-23Google Scholar
- 17.Kauppi M, Stenholm S, Impivaara O, Mäki J, Heliövaara M, Jula A (2014) Fall-related risk factors and heel quantitative ultrasound in the assessment of hip fracture risk: a 10-year follow-up of a nationally representative adult population sample. Osteoporos Int 25(6):1685–1695CrossRefPubMedGoogle Scholar
- 28.Abstracts of the eighteenth international congress of Parkinson’s disease and movement disorders, June 8–12, 2014, Stockholm, Sweden (2014). Mov Disord 29(Suppl 1):S1–S687Google Scholar
- 29.Olsen J, Nøhr EA, Thomsen RW, Støvring H (2013) Non-communicable disease epidemic: epidemiology in action (EuroEpi 2013 and NordicEpi 2013) Aarhus, Denmark from 11 August to 14 August 2013. Eur J Epidemiol 28:S1-270Google Scholar
- 38.Higgins JPT, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions. Wiley, HobokenGoogle Scholar
- 58.van Nimwegen M, Speelman AD, Smulders K, Overeem S, Borm GF, Backx FJG et al (2010) Design and baseline characteristics of the ParkFit study, a randomized controlled trial evaluating the effectiveness of a multifaceted behavioral program to increase physical activity in Parkinson patients. BMC Neurol 10(1):70CrossRefPubMedPubMedCentralGoogle Scholar