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Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review

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References

  1. Stover PJ, Field MS (2015) Vitamin B-6. Adv Nutr 6(1):132–133

    Article  CAS  Google Scholar 

  2. Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437:357–372

    Article  CAS  Google Scholar 

  3. Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D et al (1983) Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 309(8):445–448

    Article  CAS  Google Scholar 

  4. Dalton K, Dalton MJ (1987) Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand 76(1):8–11

    Article  CAS  Google Scholar 

  5. Kulkantrakorn Kongkiat (2014) Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited. Neurol Sci 35:1827–1830

    Article  Google Scholar 

  6. European Food Safety Authority (EFSA), Parma, Italy (2016) Draft scientific opinion. Scientific opinion on dietary reference values for vitamin B6. EFSA panel on dietetic products, nutrition and allergies (NDA). EFSA J 43:10–11

    Google Scholar 

  7. Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH (2004) Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 190:133–144

    Article  CAS  Google Scholar 

  8. Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM (2017) The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro 44:206–212

    Article  CAS  Google Scholar 

  9. Potter MC, Wozniak KM, Callizot N, Slusher BS (2014) Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. PLoS One 9(9):e102936

    Article  Google Scholar 

  10. Zhang W, Murakawa Y, Wozniak KM, Slusher B, Sima AA (2006) The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy. J Neurol Sci 247:217–223

    Article  CAS  Google Scholar 

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Correspondence to Johnny S. Salameh.

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Elia Malek M.D. declares that he has no conflict of interest. Hassan Doumiati, M.D. declares that he has no conflict of interest. Johnny Salameh, M.D. declares that he has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent was obtained from the individual (reported case observation) included in this paper.

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Malek, E., Doumiati, H. & Salameh, J.S. Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review. Acta Neurol Belg 120, 413–414 (2020). https://doi.org/10.1007/s13760-018-0919-7

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  • DOI: https://doi.org/10.1007/s13760-018-0919-7

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