Acta Neurologica Belgica

, Volume 117, Issue 3, pp 671–676 | Cite as

Clinical characteristics of menstrually related and non-menstrual migraine

  • Bülent Güven
  • Hayat GüvenEmail author
  • Selçuk Çomoğlu
Original Article


Migraine attacks increase during the perimenstrual period in approximately half of female migraineurs. There are differences in the pathogenesis and clinical features of menstrually related and non-menstrual migraine attacks. The objective of this study was to compare the characteristics of migraine in patients with menstrually related and non-menstrual migraine, and to investigate the differences between premenstrual, menstrual, and late-menstrual migraine attacks. Three-hundred and thirty-two women with migraine without aura were evaluated using questionnaires and diaries to determine the characteristics of headache, preceding and accompanying symptoms, and the relation of migraine attacks and menstruation. One-hundred and sixty-three women had menstrually related migraine without aura (49.1%). Duration of disease and duration of headache were longer (p = 0.002 and p < 0.001, respectively), and nausea, vomiting, phonophobia, and aggravation of headache with physical activity were more frequent in patients with menstrually related migraine (p = 0.005, p = 0.006, p < 0.001 and p = 0.006, respectively). Premonitory symptoms and allodynia were observed more frequently in the menstrually related migraine group (p = 0.012 and p = 0.004, respectively). Perimenstrual migraine attacks occurred premenstrually (days −2 and −1) in 46 patients (25.3%), menstrually (days 1 to 3) in 90 patients (49.4%), and late menstrually (days 4 to 7) in 19 patients (10.4%). Our results showed that the duration of headache was longer and accompanying symptoms were more frequent and diverse in patients with menstrually related migraine without aura, suggesting that these findings may reflect the increase in excitability or susceptibility of the brain in these patients.


Migraine Menstrually related migraine without aura Non-menstrual migraine without aura Menstruation 


Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interest.

Ethics approval

The study was carried out according to 1964 Helsinki Declaration and was approved by the Institutional Ethics Committee.

Informed consent

All patients participating in the study provided informed consent.


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Copyright information

© Belgian Neurological Society 2017

Authors and Affiliations

  1. 1.Department of NeurologyAnkara Dışkapı Yıldırım Beyazıt Training and Research HospitalAnkaraTurkey

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