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Is there any relationship between quality of life and polysomnographically detected sleep parameters/disorders in stable myasthenia gravis?

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Abstract

It is known that quality of life in myasthenia gravis is positively correlated with subjective sleep quality, still no data is available regarding the relationship between QOL and polysomnographically detected sleep parameters and disorders. In this study, we tried to highlighten this relationship, by performing polysomnography. Sleep-related complaints were evaluated in face-to-face interviews with 19 clinically stable MG patients and 26 healthy controls. During the interviews questionnaires assessing sleep quality, excessive daytime sleepiness, fatigue, depression, anxiety, and Turkish version of the MG-QOL 15-item scale [(MG-QOL15(T)] were administered and then an overnight polysomnography was performed. Sleep disorders, especially obstructive sleep apnea and fatigue were higher, whereas subjective sleep duration was significantly lower, in patients than controls. Excessive daytime sleepiness and poor sleep quality were not different between patients and controls. Other than percentage of sleep stage III, which was negatively correlated with MG-QOL15(T) scores, neither other sleep parameters nor sleep disorders were correlated with MG-QOL15(T) scores. MG composite, subjective sleep duration, fatigue severity and Hamilton depression rating scale scores were found to be positively correlated with MG-QOL15(T) scores. It was shown that decreasing disease severity and enhancing psychological well-being will improve patients’ quality of life. We recommend that our findings should be repeated in a large prospective cohort of MG patients.

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Authors and Affiliations

  1. Department of Neurology, School of Medicine, Istanbul Medipol University, Medipol Mega Hospital Complex, TEM Avrupa Otoyolu Goztepe Cikisi No: 1 Bagcilar, 34214, Istanbul, Turkey

    Nida Fatma Tascilar

  2. Sleep Disorders Center, School of Medicine, Istanbul Medipol University, Istanbul, Turkey

    Nida Fatma Tascilar

  3. Department of Psychiatry, Bulent Ecevit University Medical Faculty, Zonguldak, Turkey

    Ozge Saracli

  4. Department of Public Health, Bulent Ecevit University Medical Faculty, Zonguldak, Turkey

    Mehmet Ali Kurcer

  5. Department of Biostatistics, Duzce University Medical Faculty, Duzce, Turkey

    Handan Ankarali

  6. Department of Neurology, Istanbul Training and Research Hospital, Istanbul, Turkey

    Ufuk Emre

Authors
  1. Nida Fatma Tascilar
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  2. Ozge Saracli
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  3. Mehmet Ali Kurcer
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  4. Handan Ankarali
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  5. Ufuk Emre
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Corresponding author

Correspondence to Nida Fatma Tascilar.

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Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

This study was approved by the ethical committee of Bulent Ecevit University Clinical (No. 2012/03-15) and Istanbul Medipol University (No. 2015/03-136) non-interventional clinical research review boards, and it was in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Patients were given informed consent to participate in this study. They accepted to fill the questionnaires and to have a polysomnography.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Online resource 1 Therapy status of patients according to the Myasthenia Gravis Foundation of America (DOCX 18 kb)

13760_2017_787_MOESM2_ESM.docx

Online resource 2 Sleep architecture parameters in polysomnography in patients and controls after adjusting to HAM-D and HAM-A by covariate analyses (HAM-D and HAM-A were used as covariates) (DOCX 17 kb)

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Tascilar, N.F., Saracli, O., Kurcer, M.A. et al. Is there any relationship between quality of life and polysomnographically detected sleep parameters/disorders in stable myasthenia gravis?. Acta Neurol Belg 118, 29–37 (2018). https://doi.org/10.1007/s13760-017-0787-6

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  • DOI: https://doi.org/10.1007/s13760-017-0787-6

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