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Evaluation of benign afebrile convulsions in 16 children with rotavirus gastroenteritis

Acta Neurologica Belgica volume 117, pages 441–445 (2017)Cite this article

Abstract

In this study, we aimed to investigate the demographic, clinical, and laboratory findings of the patients hospitalized with rotavirus gastroenteritis-related afebrile seizure, retrospectively. The study population consisted of 16 patients (9 girls and 7 boys) with a mean age of 13.81 ± 5.98 months (age range 6–26). The male/female ratio was 0.77. None of the patients had any psychomotor developmental retardation. Neurological examinations of all the patients were normal. There were 7 patients with generalized tonic (43.75%), 8 generalized tonic–clonic (50%), and 1 focal seizure (6.25%). The duration of the seizures varied at a range of 2–7 min (mean 3.68 ± 1.35 min). The period between the onset of the clinical findings of the rotavirus infection and the occurrence of the seizures was ranged from 12 to 48 h (mean 31.5 ± 12.2 h). The prognosis of the rotavirus gastroenteritis-related afebrile convulsions was generally benign. Rotavirus infection should be taken into consideration in infants with gastroenteritis and afebrile convulsions.

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References

  1. Parashar UD, Burton A, Lanata C et al (2009) Global mortality associated with rotavirus disease among children in 2004. J Infect Dis 200(Suppl 1):9–15

    Article  Google Scholar 

  2. Bresee J (2008) Rotaviruses. In: Long S, Pickering LK, Prober CG (eds) Principles and practise of pediatric infectious diseases, 3rd edn. London, Churchill Livingstone Elsevier, pp 1078–1081

    Chapter  Google Scholar 

  3. Lynch M, Lee B, Azimi P et al (2001) Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis 33:932–938

    CAS  Article  PubMed  Google Scholar 

  4. Gomara MI, Auchterloine A, Zaw W et al (2002) Rotavirus gastroenteritis and CNS infection: characterization of the VP7 and VP4 genes of rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease. J Clin Microbiol 40:4797–4799

    Article  Google Scholar 

  5. Morooka K (1982) Convulsions and mild diarrhea. Shonika 35:2855–2859

    Google Scholar 

  6. Ushifima H, Bosu K, Abe T, Shimozaki T (1986) Suspected rotavirus encephalitis. Arch Dis Child 61:692–694

    Article  Google Scholar 

  7. Keidan I, Shif I, Keren G, Passwell JH (1992) Rotavirus encephalopathy: evidence of central nervous system involvement during rotavirus infection. Pediatr Infect Dis J 11:773–775

    CAS  Article  PubMed  Google Scholar 

  8. Contino MF, Lebby T, Arcinue EL (1994) Rotaviral gastrointestinal infection causing afebrile seizures in infancy and childhood. Am J Emerg Med 12:94–95

    CAS  Article  PubMed  Google Scholar 

  9. Lin SC, Hsu HY, Wang PJ, Lee CN, Chang MH, Shen YZ, Wang SM (1996) Rotavirus gastroenteritis associated with afebrile seizure in childhood. Acta Paed Sin 37:204–207

    CAS  Google Scholar 

  10. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, Boas van Emde W et al (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 51:676–685

    Article  PubMed  Google Scholar 

  11. Biçer S, Şahin GT, Koncay B et al (2008) Çocuk acil servisinde saptanan rotavirüs gastroenteriti olgularının sıklığı. J Pediatr Inf 2:96–99

    Google Scholar 

  12. Parashar UD, Gibson CJ, Bresee JS, Glass RI (2006) Rotavirus and severe childhood diarrhea. Emerg Infect Dis 12:304–306

    Article  PubMed  PubMed Central  Google Scholar 

  13. Komori H, Wada M, Eto M, Oki H, Aida K, Fujimoto T (1995) Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties. Brain Dev 17:334–337

    CAS  Article  PubMed  Google Scholar 

  14. Abe T, Kobayashi M, Araki K et al (2000) Infantile convulsions with mild gastroenteritis. Brain Dev 22:301–306

    CAS  Article  PubMed  Google Scholar 

  15. Okumura A, Uemura N, Negoro T, Watanabe K (2004) Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. Brain Dev 26:164–167

    Article  PubMed  Google Scholar 

  16. Verrotti A, Tocco AM, Coppola GG, Altobelli E, Chiarelli F (2009) A febrile benign convulsions with mild gastroenteritis: a new entity? Acta Neurol Scand 120:73–79

    CAS  Article  PubMed  Google Scholar 

  17. Goldwater P, Rowland K, Power R et al (2001) Rotavirus encephalopathy: pathogenes is reviewed. J Paediatr Child Health 37:206–209

    CAS  Article  PubMed  Google Scholar 

  18. Nishimura S, Ushijima H, Nishimura S et al (1993) Detection of rotavirus in cerebrospinal fluid and blood of patients with convulsions and gastroenteritis by means of the reverse transcription polymerase chain reaction. Brain Dev 15:457–459

    CAS  Article  PubMed  Google Scholar 

  19. Shaw D, Morehouse L, Solorzano R (1989) Rotavirus replication in colostrum- fed and colostrum-deprived pigs. Am J Vet Res 11:1966–1970

    Google Scholar 

  20. Morris A, Scott J, Ball J, Zeng C, O’Neal W, Estes M (1999) NSP4 elicits age-dependent diarrhea and Ca(2+) mediated 1(−) influx into intestinal crypts of CF mice. Am J Physiol 277:G431–G434

    CAS  PubMed  Google Scholar 

  21. Uemura N, Okumura A, Negoro T, Watanabe K (2002) Clinical features of benign convulsion with mild gastroenteritis. Brain Dev 24:745–749

    Article  PubMed  Google Scholar 

  22. Hung JJ, Wen HY, Yen MH, Chen HW, Yan DC, Lin KL et al (2003) Rotavirus gastroenteritis associated with afebrile convulsion in children: clinical analysis of 40 cases. Chang Gung Med J 26:654–659

    PubMed  Google Scholar 

  23. Kang B, Kim DH, Hong YJ, Son BK, Kim DW, Kwon YS (2013) Comparison between febrile and afebrile seizures associated with mild rotavirus gastroenteritis. Seizure 22:560–564

    Article  PubMed  Google Scholar 

  24. Youssef WF, Ramirez RP, Plana JC, Marfa MP (2011) Benign afebrile convulsions in the course of mild acute gastroenteritis: a study of 28 patients and a literature review. Pediatr Emerg Care 27:1062–1064

    Article  Google Scholar 

  25. Verrotti A, Nanni G, Agostinelli S, Parisi P, Capovilla G, Beccaria F et al (2011) Benign convulsions associated with mild gastroenteritis: a multicenter clinical study. Epilepsy Res 93:107–114

    Article  PubMed  Google Scholar 

  26. Motoyoma M, Ichiyama T, Matsushige T, Kajimoto M, Shiraishi M, Furukawa S (2009) Clinical characteristics of benign convulsions with rotavirus gastroenteritis. J Child Neurol 24:557–561

    Article  Google Scholar 

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Authors and Affiliations

  1. Clinic of Pediatrics, Beyhekim State Hospital, Konya, Turkey

    Alaaddin Yorulmaz, Sadiye Sert & Fatma Hilal Yilmaz

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  1. Alaaddin Yorulmaz
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  2. Sadiye Sert
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  3. Fatma Hilal Yilmaz
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Correspondence to Alaaddin Yorulmaz.

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Conflict of interest

No conflict of interest was declared by the authors.

Ethics committee approval

Ethics committee approval was received for this study from the Local Ethics Committee (approve number: CMRC-2016/184).

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Informed consent was obtained from all individual participants included in the study.

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The authors declared that this study has received no financial support.

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Yorulmaz, A., Sert, S. & Yilmaz, F.H. Evaluation of benign afebrile convulsions in 16 children with rotavirus gastroenteritis. Acta Neurol Belg 117, 441–445 (2017). https://doi.org/10.1007/s13760-017-0747-1

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  • DOI: https://doi.org/10.1007/s13760-017-0747-1

Keywords

  • Afebrile convulsion
  • Gastroenteritis
  • Infant
  • Rotavirus