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Addenbrooke’s cognitive examination test for brief cognitive assessment of adolescents suffering from migraine with aura

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Abstract

The aim of this study was to assess the role of the Addenbrooke’s cognitive examination test (ACE-R) in the evaluation of cognitive status in migraineurs interictally. A total of 44 adolescent patients and 44 healthy controls, matched by age and gender, have undergone ACE-R testing. Migraineurs were additionally questioned about migraine aura features and presence of higher cortical dysfunctions (HCD) during an aura. According to the questionnaire results, patients were subsequently divided into HCD and Non-HCD group. ACE-R scores of migraine patients were significantly lower than in healthy controls (93.68 ± 3.64 vs 96.91 ± 2.49; t = 4.852, p < 0.001). Also, subscores of memory and verbal fluency were significantly higher in the control population. There was no correlation of HCD occurrence with cognitive examination score, although Non-HCD subgroup achieved better score (93.13 ± 3.91 vs 94.29 ± 3.30; t = 1.053, p = 0.298). Findings have shown that migraineurs get lower ACE-R test scores, with a tendency to have a poorer outcome in more complex aura. Also, our study has revealed that the ACE-R test is an easily administered test for brief assessment of cognitive status in migraineurs. Future perspectives could be further evaluation of ACE-R test in larger sample size and the impact of migraine with aura on cognitive function in adolescents.

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References

  1. Global Burden of Disease Study 2013 Collaborators (2013) Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study. Lancet 386:743–800. doi:10.1016/S0140-6736(15)60692-4

    Google Scholar 

  2. Kernick D, Reinhold D, Campbell JL (2009) Impact of headache on young people in a school population. Br J Gen Pract 59:678–681. doi:10.3399/bjgp09X454142

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wöber-Bingöl C (2013) Epidemiology of migraine and headache in children and adolescents. Curr Pain Headache Rep 17:341. doi:10.1007/s11916-013-0341-z

    Article  PubMed  Google Scholar 

  4. Rasmussen BK, Olesen J (1992) Migraine with aura and migraine without aura: an epidemiological study. Cephalalgia 12:221–228

    Article  CAS  PubMed  Google Scholar 

  5. Hershey AD, Powers SW, Coffey CS, Eklund DD, Chamberlin LA, Korbee LL, CHAMP Study Group (2013) Childhood and Adolescent Migraine Prevention (CHAMP) study: a double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo in the prevention of childhood adolescent migraine. Headache 53:799–816. doi:10.1111/head.12105

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lampl C, Thomas H, Stovner LJ, Tassorelli C, Katsarava Z, Laínez JM, Lantéri-Minet M, Rastenyte D, Ruiz de la Torre E, Andrée C, Steiner TJ (2016) Interictal burden attributable to episodic headache: findings from the Eurolight project. J Headache Pain 17:9. doi:10.1186/s10194-016-0599-8

    Article  PubMed  PubMed Central  Google Scholar 

  7. Moutran AR, Villa TR, Diaz LA, Noffs MH, Pinto MM, Gabbai AA, Carvalho Dde S (2011) Migraine and cognition in children: a controlled study. Arq Neuropsiquiatr 69:192–195

    PubMed  Google Scholar 

  8. Zgorzalewicz M, Mojs E (2006) Assessment of chosen cognitive functions in children and adolescents with primary headaches. Przegl Lek 63:24–28

    PubMed  Google Scholar 

  9. Parisi P, Verrotti A, Paolino MC, Urbano A, Bernabucci M, Castaldo R, Villa MP (2010) Headache and cognitive profile in children: a cross-sectional controlled study. J Headache Pain 11:45–51. doi:10.1007/s10194-009-0165-8

    Article  PubMed  Google Scholar 

  10. Riva D, Usilla A, Aggio F, Vago C, Treccani C, Bulgheroni S (2012) Attention in children and adolescents with headache. Headache 52:374–384. doi:10.1111/j.1526-4610.2011.02033.x

    Article  PubMed  Google Scholar 

  11. Waldie KE, Hausmann M, Milne BJ, Poulton R (2002) Migraine and cognitive function. A life-course study. Neurology 59:904–908

    Article  PubMed  Google Scholar 

  12. Petrusic I, Pavlovski V, Vucinic D, Jancic J (2014) Features of migraine aura in teenagers. J Headache Pain 15:87. doi:10.1186/1129-2377-15-87

    Article  PubMed  PubMed Central  Google Scholar 

  13. Schipper S, Riederer F, Sándor PS, Gantenbein AR (2012) Acute confusional migraine: our knowledge to date. Expert Rev Neurother 12:307–314. doi:10.1586/ern.12.4

    Article  PubMed  Google Scholar 

  14. Le Pira F, Zappalà G, Giuffrida S, Lo Bartolo ML, Reggio E, Morana R, Lanaia F (2000) Memory disturbances in migraine with and without aura: a strategy problem? Cephalalgia 20:475–478

    Article  PubMed  Google Scholar 

  15. Riva D, Aggio F, Vago C, Nichelli F, Andreucci E, Paruta N, D’Arrigo S, Pantaleoni C, Bulgheroni S (2006) Cognitive and behavioural effects of migraine in childhood and adolescence. Cephalalgia 26:596–603

    Article  CAS  PubMed  Google Scholar 

  16. Suhr J, Seng EK (2012) Neuropsychological functioning in migraine: clinical and research implications. Cephalalgia 32:39–54. doi:10.1177/0333102411430265

    Article  PubMed  Google Scholar 

  17. Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR (2006) The Addenbrooke’s Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry 21:1078–1085

    Article  PubMed  Google Scholar 

  18. Headache Classification Committee of the International Headache Society (2004) The international classification of headache disorders, 2nd ed. Cephalalgia 24:1–160

    Google Scholar 

  19. Bharti TT, Sandeep S, Lakhan K (2013) Cognitive function in schizophrenia and its association with socio-demographics factors. Ind Psychiatry J 22:47–53. doi:10.4103/0972-6748.123619

    Article  Google Scholar 

  20. Mulder EJ, Linssen WH, Passchier J, Orlebeke JF, de Geus EJ (1999) Interictal and postictal cognitive changes in migraine. Cephalalgia 19:557–565

    Article  CAS  PubMed  Google Scholar 

  21. Wöber-Bingöl Ç, Wöber C, Uluduz D, Uygunoğlu U, Aslan TS, Kernmayer M, Zesch HE, Gerges NT, Wagner G, Siva A, Steiner TJ (2014) The global burden of headache in children and adolescents—developing a questionnaire and methodology for a global study. J Headache Pain 15:86. doi:10.1186/1129-2377-15-86

    Article  PubMed  PubMed Central  Google Scholar 

  22. Koppen H, Palm-Meinders I, Kruit M, Lim V, Nugroho A, Westhof I, Terwindt G, van Buchem M, Ferrari M, Hommel B (2011) The impact of a migraine attack and its after-effects on perceptual organization, attention, and working memory. Cephalalgia 31:1419–1427. doi:10.1177/0333102411417900

    Article  PubMed  Google Scholar 

  23. Gaist D, Pedersen L, Madsen C, Tsiropoulos I, Bak S, Sindrup S, McGue M, Rasmussen BK, Christensen K (2005) Long-term effects of migraine on cognitive function: a population-based study of Danish twins. Neurology 64:600–607

    Article  CAS  PubMed  Google Scholar 

  24. Dzoljic E, Vlajinac H, Sipetic S, Marinkovic J, Grbatinic I, Kostic V (2014) A survey of female students with migraine: what is the influence of family history and lifestyle? Int J Neurosci 124:82–87. doi:10.3109/00207454.2013.823961

    Article  PubMed  Google Scholar 

  25. Rist PM, Kang JH, Buring JE, Glymour MM, Grodstein F, Kurth T (2012) Migraine and cognitive decline among women: prospective cohort study. BMJ 345:e5027. doi:10.1136/bmj.e5027

    Article  PubMed  PubMed Central  Google Scholar 

  26. Gil-Gouveia R, Oliveira AG, Martins IP (2015) Cognitive dysfunction during migraine attacks: a study on migraine without aura. Cephalalgia 35:662–674. doi:10.1177/0333102414553823

    Article  PubMed  Google Scholar 

  27. May A (2009) Morphing voxels: the hype around structural imaging of headache patients. Brain 132:1419–1425. doi:10.1093/brain/awp116

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was partially supported by a grant from the Ministry of Science and Technology of the Republic of Serbia (Project No. 41020 and No. 175015). Professor J. Jancic has received research Grant support from the Ministry of Education and Science, Republic of Serbia (Project No. 175031).

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Authors and Affiliations

  1. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Igor Petrusic & Vera Pavlovski

  2. Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia

    Zorica Savkovic

  3. Clinic of Neurology and Psychiatry for Children and Youth, Doktora Subotica 6a, 11000, Belgrade, Serbia

    Dragana Vucinic & Jasna Jancic

  4. Department of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Branislav Filipovic

  5. Department of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Jasna Jancic

Authors
  1. Igor Petrusic
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  2. Vera Pavlovski
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  3. Zorica Savkovic
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  4. Dragana Vucinic
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  5. Branislav Filipovic
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  6. Jasna Jancic
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Correspondence to Igor Petrusic.

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The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from the parents of the child included in the study.

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Petrusic, I., Pavlovski, V., Savkovic, Z. et al. Addenbrooke’s cognitive examination test for brief cognitive assessment of adolescents suffering from migraine with aura. Acta Neurol Belg 117, 97–102 (2017). https://doi.org/10.1007/s13760-016-0655-9

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  • DOI: https://doi.org/10.1007/s13760-016-0655-9

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