Acta Neurologica Belgica

, Volume 116, Issue 1, pp 43–46 | Cite as

Serostatus of Epstein–Barr virus in Iranian MS patients

  • Sajad Karampoor
  • Hamid Zahednasab
  • Angila Ataei Pirkouh
  • Seyed Hamid Reza Monavari
  • Sreeram Ramagopalan
  • Hossein Keyvani
Original Article


Multiple sclerosis (MS) is a common, complex disorder. Associations of MS with Epstein–Barr virus (EBV) infection in Caucasian populations are well documented. However, in the Iranian population, previous studies have been conflicting. Sixty patients with MS and 50 healthy controls were tested for anti-EBV antibodies using chemiluminescent assays. All MS patients to be seropositive for EBV as compared to 82 % of controls (p = 0.0006). A strong, significant association of MS with EBV infection was documented, similar to studies in first world populations. Future studies should investigate the temporal sequence of infection to try to understand the cause of the recent increase in MS risk in Iran.


Multiple sclerosis Epstein–Barr virus Serology Environmental factors Immunoglobulin Infection 



This research was funded by Iran University of Medical Sciences (IUMS). We thank all MS patients and healthy individuals for participating in our study.

Conflict of interest

The authors declare no conflict of interest.

Ethical standard

This case control study has been performed in accordance to the statue of the ethics committee of the affiliated Iran University of Medical Sciences (IUMS).

Informed consent

Informed consent obtained from all individuals participants included in this study.


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Copyright information

© Belgian Neurological Society 2015

Authors and Affiliations

  • Sajad Karampoor
    • 1
  • Hamid Zahednasab
    • 2
  • Angila Ataei Pirkouh
    • 3
  • Seyed Hamid Reza Monavari
    • 3
  • Sreeram Ramagopalan
    • 4
  • Hossein Keyvani
    • 3
  1. 1.Department of Virology, School of Public HealthTehran University of Medical SciencesTehranIran
  2. 2.Institute of Biochemistry and BiophysicsThe University of TehranTehranIran
  3. 3.Department of Virology, School of MedicineIran University of Medical SciencesTehranIran
  4. 4.Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and GeneticsUniversity of OxfordOxfordUK

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