An evaluation of sleep quality and the prevalence of restless leg syndrome in vitamin D deficiency
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Vitamin D is known to increase levels of dopamine and its metabolites in the brain and also protects dopaminergic neurons against dopaminergic toxins. The aims of the study were to assess the frequency and symptom severity of restless leg syndrome (RLS) and sleep quality in vitamin D deficiency. A total of 102 patients were enrolled in this cross-sectional study, comprising 57 vitamin D deficient patients as Group 1 and 45 patients with normal levels of vitamin D as Group 2. RLS was diagnosed according to the International RLS Study Group (IRLSSG) diagnostic criteria. Symptom severity was assessed using the IRLSSG rating scale and sleep quality was measured with the Pittsburgh sleep quality index (PSQI). RLS incidence was higher in Group 1 (p = 0.034). The PSQI scores were higher in Group 1 and the difference between the groups was determined as statistically significant (p < 0.05). No statistically significant difference was determined in respect of the clinical evaluation and the IRLSSG Symptom Severity Scale between the patients in Group 1 diagnosed with RLS and the patients in Group 2 diagnosed with RLS (p > 0.05). The findings of this study support the hypothesis that RLS is more frequent and more severe in vitamin D deficiency and indicate a negative effect of vitamin deficiency on sleep parameters.
KeywordsVitamin D Sleep quality Restless leg syndrome Leg pain
Conflict of interest
All the authors declare that they have no conflict of interest, and the study has no financial support.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.
- 2.Bordelon P, Ghetu MV, Langan R (2009) Recognition and management of vitamin D deficiency. Am FamPhysician 80(8):841–846Google Scholar
- 4.Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87(4):1080–1086Google Scholar
- 15.Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A (2014) The effect of vitamin D supplements on the severity of restless legs syndrome. Sleep Breath. doi: 10.1007/s11325-014-1049-y
- 16.Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4(2):101–119CrossRefPubMedGoogle Scholar
- 21.Ağargün MY, Kara H, Anlar O (1996) Pittsburgh Uyku Kalitesi İndeksinin geçerliği ve güvenirliği. Türk Psikiyatri Derg 7:107–115Google Scholar