ADHD, autism and neuroradiological complications among phenylketonuric children in Upper Egypt

Acta Neurologica Belgica volume 115, pages657–663(2015)Cite this article

Abstract

The aim of this study is to evaluate the neuropsychological status in a cohort of children with early and continuously treated phenylketonuria in Assiut, Upper Egypt. The study was implemented in seventy-eight phenylketonuria (PKU) children. Only 34 patients met the inclusion criteria. Investigated patients were evaluated according to detailed history, neurological examination, Childhood Autism Rating Scale, full scale Intelligence Quotient, attention deficit hyperactivity disorder, electroencephalography and magnetic resonance imaging (MRI). This study concluded that the prognosis for early diagnosed children with PKU treated from the first weeks of life is generally good. However, they are at increased risk for neurological complications and behavioral problems. So, neonatal screening for PKU is highly recommended in Egypt, for early detection and management. In addition, neuropsychological and MRI assessments in PKU children should be done.

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Conflict of interest

All authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Author information

Affiliations

  1. Department of Pediatrics, Assiut University, Asyût, 71516, Egypt

    Khaled Saad & Ismail L. Mohamad

  2. Department of Neuropsychiatry, Assiut University, Asyût, 71516, Egypt

    Yasser Elserogy & Ahmed A. Abdel rahman

  3. Department of Psychiatry, College of Medicine, Almajmaah University, Al Majma’ah, KSA

    Abdulrahman Abdullah Al-Atram

  4. Department of Clinical Pathology, Assiut University, Asyût, 71516, Egypt

    Tarek T. H. ElMelegy

  5. Council for Nutritional and Environmental Medicine, Mo i Rana, Norway

    Geir Bjørklund

  6. Department of Community Health Nursing, Assiut University, Asyût, 71516, Egypt

    Amira A. El-Houfy

Authors
  1. Khaled Saad
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  2. Yasser Elserogy
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  3. Ahmed A. Abdel rahman
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  4. Abdulrahman Abdullah Al-Atram
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  5. Ismail L. Mohamad
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  6. Tarek T. H. ElMelegy
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  7. Geir Bjørklund
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  8. Amira A. El-Houfy
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Correspondence to Khaled Saad.

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Saad, K., Elserogy, Y., Abdel rahman, A.A. et al. ADHD, autism and neuroradiological complications among phenylketonuric children in Upper Egypt. Acta Neurol Belg 115, 657–663 (2015). https://doi.org/10.1007/s13760-014-0422-8

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Keywords

  • Phenylketonuria
  • ADHD
  • Autism
  • Children