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ADC evaluation of the corticospinal tract in multiple sclerosis


Apparent diffusion coefficient (ADC) values derived from diffusion-weighted MR imaging (DWI) provide important information about tissues. The goal of this study was to evaluate the ADC values in the corticospinal tract regions in multiple sclerosis (MS). The ADC values of 42 patients with multiple sclerosis and 46 healthy people were measured. The ADC values in the corticospinal tract at the capsula interna posterior crus from six points and mesencephalon from three points bilaterally in MS patients were compared with those of controls. An ANOVA post hoc test was used to analyse the differences in mean ADC values between the MS and control groups. The mean ADC values of the right (p = 0.008) and left internal capsules (p = 0.000) and right (p = 0.002) and left mesencephalons (p = 0.044) in MS patients were significantly lower than in the control group. There was no significant difference between the right and left side ADC values in MS (p = 0.313 vs. p = 0.223) and control groups (p = 0.756 vs. p = 0.105), respectively. The mean ADC values of the corticospinal tract in MS patients were significantly lower than in the control group. This decreased diffusion may be the result of cellular infiltration due to inflammation, cytotoxic oedema, demyelination or remyelination processes.

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The author acknowledges the help of Mehmet Ekici from the Department of Pulmonary Disease for statistical analysis.

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There are no financial disclosures, funding/support or sponsor roles to be declared.

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Correspondence to Mikail Inal.

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Inal, M., Unal, B., Kala, I. et al. ADC evaluation of the corticospinal tract in multiple sclerosis. Acta Neurol Belg 115, 105–109 (2015).

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  • Magnetic resonance imaging
  • Diffusion-weighted MRI
  • Multiple sclerosis
  • Relapsing-remitting