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Evaluation of the retinal changes in patients with chronic migraine

An Erratum to this article was published on 22 March 2013

Abstract

The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness and macular changes (central subfield thickness, cube average thickness, cube volume) in patients with chronic migraine (CM) without visual impairment using spectral-domain optical coherence tomography (SD-OCT) and to compare the results to healthy controls. A total of 80 subjects, including 40 CM patients (18 females, 12 males, at 19–36 years of age) with no migraine prophylactic treatment and 40 healthy controls (16 females, 14 males, at 20–40 years of age) were enrolled. Both eyes of patients with CM and controls were imaged using Cirrus HD SD-OCT (Carl Zeiss Meditec, Dublin, CA, USA). The average RNFL thickness was not significantly thinner in patients with CM. The mean average RNFL thickness was 83 ± 10.5 μm in CM patients and 85 ± 9.6 μm in healthy controls (p = 0.648), but superior quadrant RNFL thickness in the CM patients was significantly lower than healthy controls. The mean superior RNFL thickness was 86 ± 6.7 μm in CM patients and 108 ± 7.3 μm in controls (p < 0.001). Illness duration and frequency of the attacks were not affected by RNFL thickness. No significant differences were detected in macular changes between CM patients and healthy controls. In our study, the thickness of superior RNFL was found to be thinner in CM patients. This implies that longitudinal follow-up is needed to clarify whether RNFL thinning, in migraine patients, is related to a progressive loss of axons and retinal ganglion cells.

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References

  1. Lipton R, Bigal M, Diamond M, Freitag F, Reed M, Stewart W (2007) Migraine prevalence, disease burden and the need for preventive therapy. Neurology 68:343–349

    PubMed  Article  CAS  Google Scholar 

  2. Diener HC, Dodick DW, Goadsby PJ, Lipton RB, Olesen J, Silberstein SD (2012) Chronic-migraine-classification, characteristics and treatment. Nat Rev Neurol 8:162–171

    PubMed  Article  CAS  Google Scholar 

  3. Carod-Artal FJ, Irimia P, Ezpeleta D (2012) Chronic migraine: definition, epidemiology, risk factors and treatment. Rev Neurol 54:629–637

    PubMed  Google Scholar 

  4. Kurth T, Chabriat H, Bousser MG (2012) Migraine and stroke: a complex association with clinical implications. Lancet Neurol 11:92–100

    PubMed  Article  Google Scholar 

  5. Killer HE, Forrer A, Flammer J (2003) Retinal vasospasm during an attack of migraine. Retina 23:253–254

    PubMed  Article  Google Scholar 

  6. Kruit MC, Van Buchem Ma, Hofman PAM (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434

    PubMed  Article  CAS  Google Scholar 

  7. Tan FU, Akarsu C, Güllü R (2005) Retinal nerve fiber layer thickness is unaffected in migraine patients. Acta Neurol Scand 112:19–23

    PubMed  Article  CAS  Google Scholar 

  8. Martinez A, Proupim N, Sanchez M (2008) Retinal nerve fiber layer thickness measurements using optical coherence tomography in migraine patients. Br J Ophthalmol 92:1069–1075

    PubMed  Article  CAS  Google Scholar 

  9. Gipponi S, Scaroni N, Venturelli E, Forbice E, Rao R, Liberini P, Padovani A, Semeraro F. Reduction in retinal nerve fiber layer thickness in migraine patients. Neurol Sci. doi:10.1007/s10072-012-1103-0

  10. Pasol J (2011) Neuro-ophthalmic disease and optical coherence tomography: glaucoma look-alikes. Curr Opin Ophthalmol 22:124–132

    PubMed  Article  Google Scholar 

  11. Greenberg BM, Frohman E (2010) Optical coherence tomography as a potential readout in clinical trials. Ther Adv Neurol Disord 3:153–160

    PubMed  Article  Google Scholar 

  12. Headache Classification Committee, Olesen J, Bousser MG et al (2006) New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 26:742–746

    PubMed  Article  CAS  Google Scholar 

  13. Ahlers C, Schmidt-Erfurth U (2009) Three-dimensional high resolution OCT imaging of macular pathology. Opt Express 17:4037–4045

    PubMed  Article  CAS  Google Scholar 

  14. Kara SA, Erdemoglu AK, Karadeniz MY, Altinok D (2003) Color Doppler sonography of orbital and vertebral arteries in migraineurs without aura. J Clin Ultrasound 31:308–314

    PubMed  Article  Google Scholar 

  15. Purdy RA (2011) The role of the visual system in migraine: an update. Neurol Sci 32:89–93

    Article  Google Scholar 

  16. Tahiri Joutei Hassani R, Dupont Monod S, Oukacha G, Mantout F, Benrabah R, Heron H, Baudoin C (2010) Acute bilateral angle-closure glaucoma induced by topiramate: contribution of Visante OCT. J Fr Ophthalmol 33:307–311

    Article  CAS  Google Scholar 

  17. Ozturk BT, Genç E, Tokgoz M, Kerimoglu H, Genc BO (2011) Ocular changes associated with topiramate. Curr Eye Res 36:47–52

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Serkan Kirbas.

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Kirbas, S., Tufekci, A., Turkyilmaz, K. et al. Evaluation of the retinal changes in patients with chronic migraine. Acta Neurol Belg 113, 167–172 (2013). https://doi.org/10.1007/s13760-012-0150-x

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  • DOI: https://doi.org/10.1007/s13760-012-0150-x

Keywords

  • Chronic migraine
  • Retinal nerve fiber layer
  • Macula thickness
  • Optical coherence tomography