Skip to main content

Correlation between motor performance scales, body composition, and anthropometry in patients with duchenne muscular dystrophy

Abstract

The aim of this study is to investigate the relationship between body composition, anthropometry, and motor scales in patients with Duchenne muscular dystrophy (DMD). Twenty six patients with DMD were evaluated by Expanded Hammersmith Functional Motor Scale (HFMSE), gross motor function classification system (GMFCS), multifrequency bioelectrical impedance analysis, and anthropometric measurements. Seventeen healthy children served as control group. There were 26 patients with a mean age of 9.5 ± 4.8 years. Ages and anthropometric measurements did not differ between groups. Of the 26 patients, nine were level I, seven were level II, two were level III, seven were level IV, and one was level V, according to the GMFCS. Despite the similar percentage of total body water, extracellular water/intracellular water ratio was significantly elevated in DMD patients (p = 0.001). Increased values of fat percentage and body fat mass index (BFMI) correlated positively with elevated GMFCS levels (r = 0.785 and 0.719 respectively). Increased fat-free mass index (FFMI) correlated negatively with elevated GMFCS levels (r = −0.401). Increased fat percentage and BFMI correlated negatively with HFMSE scores (r = −0.779 and −0.698, respectively). Increased values of FFMI correlated positively with HFMSE scores. There was also a negative correlation between increased skin fold measurements from triceps and scapula and HFMSE scores (r = −0.618 and −0.683, respectively). Increased skin fold values from the same regions correlated positively with elevated GMFCS levels (r = 0.643 and 0.712, respectively). Significant body composition changes occur in patients with DMD. Anthropometric and multifrequency bioelectrical impedance analyses measurements show good correlation between motor function scales. These results may also be helpful to evaluate the effects of new treatment strategies.

This is a preview of subscription content, access via your institution.

References

  1. Eagle M, Baudouin SV, Chandler C, Giddings DR, Bullock R, Bushby K (2002) Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation. Neuromuscul Disord 12:926–929

    PubMed  Article  Google Scholar 

  2. Fairclough RJ, Bareja A, Davies KE (2011) Progress in therapy for Duchenne muscular dystrophy. Exp Physiol 96:1101–1113

    PubMed  Article  CAS  Google Scholar 

  3. Bhagavati S (2012) Exon-skipping therapy for Duchenne muscular dystrophy. Lancet 379:10–11

    Article  Google Scholar 

  4. McDonald CM, Carter GT, Abresch RT et al (2005) Body composition and water compartment measurements in boys with Duchenne muscular dystrophy. Am J Phys Med Rehabil 84:483–491

    PubMed  Article  Google Scholar 

  5. Mok E, Beghin L, Gachon P et al (2006) Estimating body composition in children with Duchenne muscular dystrophy: comparison of bioelectrical impedance analysis and skinfold-thickness measurement. Am J Clin Nutr 83:65–69

    PubMed  CAS  Google Scholar 

  6. Jaffrin MY, Morel H (2008) Body fluid volumes measurements by impedance: a review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods. Med Eng Phys 30(10):1257–1269

    PubMed  Article  Google Scholar 

  7. Silva EC, Machado DL, Resende MB, Silva RF, Zanoteli E, Reed UC (2012) Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy. Arq Neuropsiquiatr 70(3):191–195

    PubMed  Google Scholar 

  8. Scott E, Eagle M, Mayhew A et al (2011) Development of a Functional Assessment Scale for Ambulatory Boys with Duchenne Muscular Dystrophy. Physiother Res Int. doi:10.1002/pri.520

  9. O’Hagen JM, Glanzman AM, McDermott MP et al (2007) An expanded version of the Hammersmith Functional Motor Scale for SMA II and III patients. Neuromuscul Disord 17:693–697

    PubMed  Article  Google Scholar 

  10. Mercuri E, Messina S, Battini R et al (2006) Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study. Neuromuscul Disord 16(2):93–98

    PubMed  Article  CAS  Google Scholar 

  11. Krosschell KJ, Scott CB, Maczulski JA, Lewelt AJ, Reyna SP, Project Cure SMA (2011) Reliability of the Modified Hammersmith Functional Motor Scale in young children with spinal muscular atrophy. Muscle Nerve 44(2):246–251

    PubMed  Article  Google Scholar 

  12. Parreira SL, Resende MB, Zanoteli E, Carvalho MS, Marie SK, Reed UC (2010) Comparison of motor strength and function in patients with Duchenne muscular dystrophy with or without steroid therapy. Arq Neuropsiquiatr 68(5):683–688

    PubMed  Article  Google Scholar 

  13. Palisano R, Rosenbaum P, Walter S, Russell D, Wood E, Galuppi B (1997) Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol 39(4):214–223

    PubMed  Article  CAS  Google Scholar 

  14. Palisano RJ, Rosenbaum P, Bartlett D, Livingston MH (2008) Content validity of the expanded and revised gross motor function classification system. Dev Med Child Neurol 50:744–750

    PubMed  Article  Google Scholar 

  15. Carnahan KD, Arner M, Hägglund G (2007) Association between gross motor function (GMFCS) and manual ability (MACS) in children with cerebral palsy. A population-based study of 359 children. BMC Musculoskelet Disord 8:50

    PubMed  Article  Google Scholar 

  16. Biggar WD, Gingras M, Fehlings DL, Harris VA, Steele CA (2001) Deflazacort treatment of Duchenne muscular dystrophy. J Pediatr 138(1):45–50

    PubMed  Article  CAS  Google Scholar 

  17. Willig TN, Carlier L, Legrand M, Riviere H, Navarro J (1993) Nutritional assessment in Duchenne muscular dystrophy. Dev Med Child Neurol 35:1074–1082

    PubMed  Article  CAS  Google Scholar 

  18. Griffiths RD, Edwards RH (1988) A new chart for weight control in Duchenne muscular dystrophy. Arch Dis Child 63:1256–1258

    PubMed  Article  CAS  Google Scholar 

  19. Leroy-Willig A, Willig TN, Henry-Feugeas MC et al (1997) Body composition determined with MR in patients with Duchenne muscular dystrophy, spinal muscular atrophy, and normal subjects. Magn Reson Imaging 15:737–744

    PubMed  Article  CAS  Google Scholar 

  20. Edmonds CJ, Smith T, Griffiths RD, Mackenzie J, Edwards RH (1985) Total body potassium and water, and exchangeable sodium, in muscular dystrophy. Clin Sci (Lond) 68(4):379–385

    CAS  Google Scholar 

  21. Pessolano FA, Súarez AA, Monteiro SG, Mesa L et al (2003) Nutritional assessment of patients with neuromuscular diseases. Am J Phys Med Rehabil 82(3):182–185

    PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Erhan Bayram.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bayram, E., Topcu, Y., Karakaya, P. et al. Correlation between motor performance scales, body composition, and anthropometry in patients with duchenne muscular dystrophy. Acta Neurol Belg 113, 133–137 (2013). https://doi.org/10.1007/s13760-012-0125-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13760-012-0125-y

Keywords

  • Duchenne muscular dystrophy
  • Motor function
  • Body composition
  • Skinfold thickness
  • Bioelectrical impedance analysis