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Primary breast lymphoma sequentially relapsed in the peripheral and central nervous system

Abstract

Primary breast lymphoma (PBL) is an uncommon extranodal type of lymphoma, exhibiting more aggressive behavior and poorer prognosis. Patients with PBL have a higher incidence to relapse in central nervous system (CNS), which is always leading to a dismal outcome even treating with high intensity chemotherapy plus radiotherapy. Lymphoma involving the peripheral nervous system (PNS), either primarily or secondarily, is also rare. But no PBL with PNS relapse has been reported before. Herein, we reported a case of PBL who presented with subsequent relapse in two discrete sites of the PNS followed by the CNS.

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References

  1. Wong WW, Schild SE, Halyard MY, Schomberg PJ (2002) Primary non-hodgkin lymphoma of the breast. The mayo clinic experience. J Surg Oncol 80:19–25 (discussion 26)

    PubMed  Article  Google Scholar 

  2. Guo HY, Zhao XM, Li J, Hu XC (2008) Primary non-hodgkin’s lymphoma of the breast. Eight-year follow-up experience. Int J Hematol 87:491–497

    PubMed  Article  Google Scholar 

  3. Lin YC, Tsai CH, Wu JS, Huang CS, Kuo SH et al (2009) Clinicopathologic features and treatment outcome of non-hodgkin lymphoma of the breast—a review of 42 primary and secondary cases in taiwanese patients. Leuk Lymphoma 50:918–924

    PubMed  Article  CAS  Google Scholar 

  4. Julen O, Dellacasa I, Pelte MF, Borish B, Bouchardy C et al (2009) Primary breast lymphomas. Rare Tumors e1:e14

    Google Scholar 

  5. Jeanneret-Sozzi W, Taghian A, Epelbaum R, Poortmans P, Zwahlen D et al (2008) Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study. BMC Cancer 8:86

    PubMed  Article  Google Scholar 

  6. Yhim HY, Kang HJ, Choi YH, Kim SJ, Kim WS et al (2010) Clinical outcomes and prognostic factors in patients with breast diffuse large b cell lymphoma; consortium for improving survival of lymphoma (cisl) study. BMC Cancer 10:321

    PubMed  Article  Google Scholar 

  7. Yamazaki H, Hanada M, Kitada M, Kuyama J, Sato T et al (2003) Four cases of central nervous system involvement of breast malignant lymphoma. Jpn J Clin Oncol 33:399–403

    PubMed  Article  Google Scholar 

  8. Aviles A, Delgado S, Nambo MJ, Neri N, Murillo E et al (2005) Primary breast lymphoma: results of a controlled clinical trial. Oncology 69:256–260

    PubMed  Article  Google Scholar 

  9. Ryan G, Martinelli G, Kuper-Hommel M, Tsang R, Pruneri G et al (2008) Primary diffuse large b-cell lymphoma of the breast: prognostic factors and outcomes of a study by the international extranodal lymphoma study group. Ann Oncol 19:233–241

    PubMed  Article  CAS  Google Scholar 

  10. Aviles A, Castaneda C, Neri N, Cleto S, Nambo MJ (2007) Rituximab and dose dense chemotherapy in primary breast lymphoma. Haematologica 92:1147–1148

    PubMed  Article  CAS  Google Scholar 

  11. Jennings WC, Baker RS, Murray SS, Howard CA, Parker DE et al (2007) Primary breast lymphoma: the role of mastectomy and the importance of lymph node status. Ann Surg 245:784–789

    PubMed  Article  Google Scholar 

  12. Roncaroli F, Poppi M, Riccioni L, Frank F (1997) Primary non-hodgkin’s lymphoma of the sciatic nerve followed by localization in the central nervous system: case report and review of the literature. Neurosurgery 40:618–621 (discussion 621-612)

    PubMed  CAS  Google Scholar 

  13. Peruzzi P, Ray-Chaudhuri A, Slone WH, Mekhjian HS, Porcu P et al (2009) Reversal of neurological deficit after chemotherapy in bcl-6-positive neurolymphomatosis. Case report. J Neurosurg 111:247–251

    PubMed  Article  Google Scholar 

  14. Chamberlain MC, Fink J (2009) Neurolymphomatosis: a rare metastatic complication of diffuse large b-cell lymphoma. J Neurooncol 95:285–288

    PubMed  Article  Google Scholar 

  15. Peris K, Fargnoli MC, Berardelli A, Crecco M, Tomaselli R et al (1998) Peripheral nervous system involvement in a patient with large t-cell lymphoma arising from a pre-existing mycosis fungoides. Br J Dermatol 139:299–301

    PubMed  Article  CAS  Google Scholar 

  16. Bai LY, Chiu CF, Liao YM, Yeh SP, Lin CY et al (2007) Recurrent lymphoma presenting as brachial plexus neuropathy. J Clin Oncol 25:726–728

    PubMed  Article  Google Scholar 

  17. Ghobrial IM, Buadi F, Spinner RJ, Colgan JP, Wolanskyj AP et al (2004) High-dose intravenous methotrexate followed by autologous stem cell transplantation as a potentially effective therapy for neurolymphomatosis. Cancer 100:2403–2407

    PubMed  Article  CAS  Google Scholar 

  18. Bronstein Y, Tummala S, Rohren E (2011) F-18 fdg pet/ct for detection of malignant involvement of peripheral nerves: case series and literature review. Clin Nucl Med 36:96–100

    PubMed  Article  Google Scholar 

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Correspondence to Tzung-Chih Tang.

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Tang, TC., Chang, H. & Chuang, WY. Primary breast lymphoma sequentially relapsed in the peripheral and central nervous system. Acta Neurol Belg 112, 271–274 (2012). https://doi.org/10.1007/s13760-012-0052-y

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  • DOI: https://doi.org/10.1007/s13760-012-0052-y

Keywords

  • Primary breast lymphoma
  • Relapse
  • Peripheral nervous system