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Hormonal therapy for fertility and huge meningioma: a purely random association?


Sexual hormones have been related to the growth of meningiomas, also due to the almost constant expression of hormonal receptors by tumoral cells. A case of a woman with previous history of multiple treatment for infertility, harboring a huge meningioma is here described. The tumor was surgically resected and the immunohistochemical examination revealed a high expression of progesterone receptors on tumoral cells surface. A putative role of past progesterone administration in the growth of meningioma has been hypothesized. Particular caution should be paid whenever adopting sexual hormonal therapy, especially for fertility. A radiological examination (ideally MRI) could be advised before starting therapy, in order to rule out any intracranial meningioma.

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Correspondence to Pier Paolo Mattogno.

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Frassanito, P., De Bonis, P., Mattogno, P.P. et al. Hormonal therapy for fertility and huge meningioma: a purely random association?. Acta Neurol Belg 112, 299–301 (2012).

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  • Meningioma
  • Progesterone
  • Fertility therapy
  • Sex hormonal receptors