Skip to main content

As a rare cause of drug-induced cough: topiramate

Abstract

The most common causes of chronic cough in nonsmokers are postnasal drip syndrome, asthma, and gastroesophageal reflux disease. Drugs are also important in the etiology of resistant cough. Most common drugs inducing cough are the ACE inhibitors. Many drugs other than ACE inhibitors can also cause dry cough and one among them is topiramate. It is a new generation, efficacy-proved antiepileptic drug that is used widely for migraine prophylaxis in many countries. Most common adverse events of topiramate are paresthesia, cognitive symptoms, fatigue, insomnia, nausea, loss of apetite, anxiety, and dizziness. There is only one case report about topiramate associated cough in the literature. The present report refers to a patient, presenting with cough who is on topiramate treatment for migraine prophylaxis.

This is a preview of subscription content, access via your institution.

Abbreviations

ACE:

Angiotensinogen converting enzyme

GERD:

Gastroesophageal reflux disease

ESR:

Erythrocyte sedimentation rate

CBC:

Complete blood count

CT:

Computed tomography

GABA:

Gamma aminobutyric acid

NMDA:

N-methyl-d-aspartate

RAR:

Rapidly adapting receptors

References

  1. Madison JM, Irwin RS (2010) Cough:a worldwide problem. Otolaryngol Clin North Am 43(1):1–13

    PubMed  Article  Google Scholar 

  2. Chung KF, Pavord ID (2008) Prevalance, pathogenesis, and causes of chronic cough. Lancet 371(9621):1364–1374

    PubMed  Article  Google Scholar 

  3. Vegter S, de Jong-van den Berg LT (2010) Misdiagnosis and mistreatment of common side effect angiotensin-converting enzyme inhibitor induced cough. Br J Clin Pharmacol 69(2):200–203

    PubMed  Article  Google Scholar 

  4. Dicpinigaitis PV (2006) Angiotensin-converting enzyme inhibitor induced cough:evidence based clinical practice guidelines. Chest 129(1):169–173

    Article  Google Scholar 

  5. Silberstein SD (2005) Topiramate in migrain prevention. Headache 45(1):57–65

    Article  Google Scholar 

  6. Shank RP, Gardocki JF, Strreeter AJ, Maryanoff BE (2000) An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia 41(1):3–9

    Article  Google Scholar 

  7. Czapinski P, Blaszczyk B, Czuczwar SJ (2005) Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 5(1):3–14

    PubMed  Article  CAS  Google Scholar 

  8. Evers S (2008) Treatment of migraine with prophylactic drugs. Expert Opin Pharmacother 9:2565–2573

    PubMed  Article  CAS  Google Scholar 

  9. Wenzel RG, Schwartz K, Padiyara RS (2006) Topiramate for migraine prevention. Pharmacotherapy 26(3):375–387

    PubMed  Article  CAS  Google Scholar 

  10. Lainez MJ, Freitag FG, Pfeil J, Ascher S, Olson WH, Schwalen S (2007) Time course of adverse events most commonly associated with topiramate for migraine prevention. Eur J Neurol 14(8):900–906

    PubMed  Article  CAS  Google Scholar 

  11. Silberstein SD, Lipton RB, Dodick DW, Freitag FG, Ramadan N (2007) Efficiacy and safety of topiramate for the treatment of chronic migrain: a randomized, double blind, placebo controlled trial. Headache 47(2):170–180

    PubMed  Article  Google Scholar 

  12. Ferdinando Maggioni MD, Edoardo Mampreso MD, Federico Mainardi MD, Carlo Lisotto MD (2010) Topiramate induced intractable cough during migrain prophylaxis. Headache 50:301–304

    PubMed  Article  Google Scholar 

  13. John G (1996) Widdicombe. Sensory neurophysiology of the cough reflex. J Allerg Clin Immunol 98(5 Pt 2):S84–S89

    Google Scholar 

  14. Widdicombe J (2002) Neuroregulation of cough: implication for drug therapy. Current Op.Pharm 2:254–263

    Google Scholar 

Download references

Conflict of interest

None declared.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Emine Tosun.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tosun, E., Topaloğlu, O. & Akkalyoncu, B. As a rare cause of drug-induced cough: topiramate. Acta Neurol Belg 112, 217–220 (2012). https://doi.org/10.1007/s13760-012-0016-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13760-012-0016-2

Keywords

  • Migraine
  • Topiramate
  • Angiotensin Converting Enzyme Inhibitor
  • Migraine Attack
  • Gastroesophageal Reflux Disease