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As a rare cause of drug-induced cough: topiramate


The most common causes of chronic cough in nonsmokers are postnasal drip syndrome, asthma, and gastroesophageal reflux disease. Drugs are also important in the etiology of resistant cough. Most common drugs inducing cough are the ACE inhibitors. Many drugs other than ACE inhibitors can also cause dry cough and one among them is topiramate. It is a new generation, efficacy-proved antiepileptic drug that is used widely for migraine prophylaxis in many countries. Most common adverse events of topiramate are paresthesia, cognitive symptoms, fatigue, insomnia, nausea, loss of apetite, anxiety, and dizziness. There is only one case report about topiramate associated cough in the literature. The present report refers to a patient, presenting with cough who is on topiramate treatment for migraine prophylaxis.

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Angiotensinogen converting enzyme


Gastroesophageal reflux disease


Erythrocyte sedimentation rate


Complete blood count


Computed tomography


Gamma aminobutyric acid




Rapidly adapting receptors


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Correspondence to Emine Tosun.

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Tosun, E., Topaloğlu, O. & Akkalyoncu, B. As a rare cause of drug-induced cough: topiramate. Acta Neurol Belg 112, 217–220 (2012).

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  • Migraine
  • Topiramate
  • Angiotensin Converting Enzyme Inhibitor
  • Migraine Attack
  • Gastroesophageal Reflux Disease