Abstract
Diabetes mellitus has been regarded as one of the prime health issues in present days, which can often lead to diabetic retinopathy, a complication of the disease that affects the eyes, causing loss of vision. For precisely detecting the condition’s existence, clinicians are required to recognise the presence of lesions in colour fundus images, making it an arduous and time-consuming task. To deal with this problem, a lot of work has been undertaken to develop deep learning-based computer-aided diagnosis systems that assist clinicians in making accurate diagnoses of the diseases in medical images. Contrariwise, the basic operations involved in deep learning models lead to the extraction of a bulky set of features, further taking a long period of training to predict the existence of the disease. For effective execution of these models, feature selection becomes an important task that aids in selecting the most appropriate features, with an aim to increase the classification accuracy. This research presents an optimised deep k-nearest neighbours’-based pipeline model in a bid to amalgamate the feature extraction capability of deep learning models with nature-inspired metaheuristic algorithms, further using k-nearest neighbour algorithm for classification. The proposed model attains an accuracy of 97.67 and 98.05% on two different datasets considered, outperforming Resnet50 and AlexNet deep learning models. Additionally, the experimental results also portray an analysis of five different nature-inspired metaheuristic algorithms, considered for feature selection on the basis of various evaluation parameters.
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Data availability
Dataset used in this article was obtained from the Kaggle (https://www.kaggle.com/sovitrath/diabetic-retinopathy-224x224-gaussian-filtered).
References
Islam MM, Yang HC, Poly TN, Jian WS, Li YCJ. Deep learning algorithms for detection of diabetic retinopathy in retinal fundus photographs: a systematic review and meta-analysis. Comput Methods Programs Biomed. 2020;191:105320.
Pires R, Avila S, Wainer J, Valle E, Abramoff MD, Rocha A. A data-driven approach to referable diabetic retinopathy detection. Artif Intell Med. 2019;96:93–106.
Shankar K, Sait ARW, Gupta D, Lakshmanaprabu SK, Khanna A, Pandey HM. Automated detection and classification of fundus diabetic retinopathy images using synergic deep learning model. Pattern Recognit Lett. 2020;133:210–6.
Gayathri S, Gopi VP, Palanisamy P. A lightweight CNN for diabetic retinopathy classification from fundus images. Biomed Signal Process Control. 2020;62:102115.
Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62(1):3–16.
Bäcklund L, Algvere P, Rosenqvist U. New blindness in diabetes reduced by more than one-third in Stockholm County. Diabet Med. 1997;14(9):732–40.
Congdon NG, Friedman DS, Lietman T. Important causes of visual impairment in the world today. JAMA. 2003;290(15):2057–60.
Canayaz M. MH-COVIDNet: diagnosis of COVID-19 using deep neural networks and meta-heuristic-based feature selection on X-ray images. Biomed Signal Process Control. 2021;64:102257.
Dwivedi SA, Attry A. (2021). Juxtaposing deep learning models efficacy for ocular disorder detection of diabetic retinopathy for ophthalmoscopy. In 2021 6th International Conference on Signal Processing, Computing and Control (ISPCC). IEEE.
Dai L, Wu L, Li H, Cai C, Wu Q, Kong H, Jia W. A deep learning system for detecting diabetic retinopathy across the disease spectrum. Nat commun. 2021;12(1):3242.
Jena PK, Khuntia B, Palai C, Nayak M, Mishra TK, Mohanty SN. A novel approach for diabetic retinopathy screening using asymmetric deep learning features. Big Data Cogn Comput. 2023;7(1):25.
Saranya P, Pranati R, Patro SS. Detection and classification of red lesions from retinal images for diabetic retinopathy detection using deep learning models. Multimed Tools Appl. 2023. https://doi.org/10.1007/s11042-023-15045-1.
Tsiknakis N, Theodoropoulos D, Manikis G, Ktistakis E, Boutsora O, Berto A, Marias K. Deep learning for diabetic retinopathy detection and classification based on fundus images: a review. Comput Biol Med. 2021;135:104599.
Burcu OLTU, Karaca BK, Erdem H, Özgür A. A systematic review of transfer learning-based approaches for diabetic retinopathy detection. Gazi Univ J Sci. 2021. https://doi.org/10.35378/gujs.1081546.
Badgujar RD, Deore PJ. Hybrid nature inspired SMO-GBM classifier for exudate classification on fundus retinal images. IRBM. 2019;40(2):69–77.
Mrad Y, Elloumi Y, Akil M, Bedoui MH. A fast and accurate method for glaucoma screening from smartphone-captured fundus images. Irbm. 2022;43(4):279–89.
Wu Y, Hu Z. (2019). Recognition of diabetic retinopathy based on transfer learning. In 2019 IEEE 4th International Conference on Cloud Computing and Big Data Analysis (ICCCBDA). IEEE.
Khalifa NEM, Loey M, Taha MHN, Mohamed HN E. T. Deep transfer learning models for medical diabetic retinopathy detection. Acta Informatica Med. 2019;27(5):327.
Gangwar AK, Ravi V. iabetic retinopathy detection using transfer learning and deep learning. Evol Comput Intell: Front Intell Comput: Theory Appl. 2021;1:679–89.
Patel R, Chaware A. (2020). Transfer learning with fine-tuned MobileNetV2 for diabetic retinopathy. In 2020 international conference for emerging technology (INCET). IEEE.
Al-Smadi M, Hammad M, Baker QB, Sa’ad A. A transfer learning with deep neural network approach for diabetic retinopathy classification. Int J Electr Comput Eng. 2021;11(4):3492.
Salvi RS, Labhsetwar SR, Kolte PA, Venkatesh VS, Baretto AM. (2021). Predictive analysis of diabetic retinopathy with transfer learning. In 2021 4th Biennial International Conference on Nascent Technologies in Engineering (ICNTE). IEEE.
Sanjana S, Shadin NS, Farzana M. (2021). Automated diabetic retinopathy detection using transfer learning models. In 2021 5th International Conference on Electrical Engineering and Information Communication Technology (ICEEICT). IEEE.
Al-Haija QA, Adebanjo A. (2020). Breast cancer diagnosis in histopathological images using ResNet-50 convolutional neural network. In 2020 IEEE International IOT, Electronics and Mechatronics Conference (IEMTRONICS)). IEEE.
Apostolopoulos ID, Mpesiana TA. Covid-19: automatic detection from x-ray images utilizing transfer learning with convolutional neural networks. Phys Eng Sci Med. 2020;43:635–40.
Russakovsky O, Deng J, Su H, Krause J, Satheesh S, Ma S, Fei-Fei L. Imagenet large scale visual recognition challenge. Int J Comput Vis. 2015;115:211–52.
Jha R, Bhattacharjee V, Mustafi A. Transfer Learning with Feature Extraction Modules for Improved Classifier Performance on Medical Image Data. Sci Program. 2022. https://doi.org/10.1155/2022/4983174.
Krizhevsky A, Sutskever I, Hinton GE. Imagenet classification with deep convolutional neural networks. Commun ACM. 2017;60(6):84–90.
He K, Zhang X, Ren S, Sun J. (2016). Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition.
He K, Zhang X, Ren S, Sun J. (2016). Identity mappings in deep residual networks. In Computer Vision–ECCV 2016: 14th European Conference, Amsterdam, The Netherlands, October 11–14, 2016, Proceedings, Part IV 14.
He K, Zhang X, Ren S, Sun J. Deep residual learning. Image Recogn. 2015. https://doi.org/10.1109/CVPR.2016.90.
Ji Q, Huang J, He W, Sun Y. Optimized deep convolutional neural networks for identification of macular diseases from optical coherence tomography images. Algorithms. 2019;12(3):51.
Apdullah Y. (2023). Feature selection (https://github.com/apdullahyayik/Feature-Selection), GitHub. Accessed 16 June 2023.
Emary E, Zawbaa HM, Hassanien AE. Binary grey wolf optimization approaches for feature selection. Neurocomputing. 2016;172:371–81.
Hans R, Kaur H. Binary multi-verse optimization (BMVO) approaches for feature selection. Int J Interact Multimedia Artif Intell. 2020;6:91–106.
Altman NS. An introduction to kernel and nearest-neighbor nonparametric regression. Am Stat. 1992;46(3):175–85.
Rath SR. (2019) Diabetic retinopathy 224 × 224 gaussian filtered, https://www.kaggle.com/sovitrath/diabetic-retinopathy-224x224-gaussian-filtered.
Goldberg D. Genetic algorithms in search, optimization, and machine learning. Reading: Addison-Wesley; 1989.
Kennedy J, Eberhart R. (1995) Particle swarm optimization. In Proceedings of the IEEE International Conference on Neural Network, Perth, Australia.
Simon D. Biogeography-based optimization. IEEE Trans Evol Comput. 2008;12:702–13.
Mirjalili S, Mirjalili SM, Lewis A. Grey wolf optimizer. Adv Eng Softw. 2014;69:46–61.
Mirjalili S, Gandomi AH, Mirjalili SZ, Saremi S, Faris H, Mirjalili SM. Salp swarm algorithm: a bio-inspired optimizer for engineering design problems. Adv Eng Softw. 2017;114:163–91.
Ramachandran SK, Manikandan P. An efficient ALO-based ensemble classification algorithm for medical big data processing. Int J Med Eng Inf. 2021;13(1):54–63.
Thota NB, Reddy DU. (2020). Improving the accuracy of diabetic retinopathy severity classification with transfer learning. In 2020 IEEE 63rd International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE.
Ramchandre S, Patil B, Pharande S, Javali K, Pande H. (2020). A deep learning approach for diabetic retinopathy detection using transfer learning. In 2020 IEEE International Conference for Innovation in Technology (INOCON). IEEE.
Islam KT, Wijewickrema S, O’Leary S. (2019). Identifying diabetic retinopathy from oct images using deep transfer learning with artificial neural networks. In 2019 IEEE 32nd international symposium on computer-based medical systems (CBMS). IEEE.
Dong B, Wang X, Qiang X, Du F, Gao L, Wu Q, Dai C. A multi-branch convolutional neural network for screening and staging of diabetic retinopathy based on wide-field optical coherence tomography angiography. IRBM. 2022;43(6):614–20.
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R.H. applied the algorithms and computed the results from the proposed model. S.K.S. performed the graphical analysis of the results. Both R.H. and S.K.S. worked on the development of the first draft of the manuscript. U.A. did the meticulous proofreading of the manuscript and suggested section wise improvements in the manuscript. All authors read and approved the final manuscript.
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Hans, R., Sharma, S.K. & Aickelin, U. Optimised deep k-nearest neighbour’s based diabetic retinopathy diagnosis(ODeep-NN) using retinal images. Health Inf Sci Syst 12, 23 (2024). https://doi.org/10.1007/s13755-024-00282-x
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DOI: https://doi.org/10.1007/s13755-024-00282-x