Advertisement

Transfer learning based histopathologic image classification for breast cancer detection

  • Erkan Deniz
  • Abdulkadir Şengür
  • Zehra Kadiroğlu
  • Yanhui Guo
  • Varun Bajaj
  • Ümit Budak
Research
  • 37 Downloads

Abstract

Breast cancer is one of the leading cancer type among women in worldwide. Many breast cancer patients die every year due to the late diagnosis and treatment. Thus, in recent years, early breast cancer detection systems based on patient’s imagery are in demand. Deep learning attracts many researchers recently and many computer vision applications have come out in various environments. Convolutional neural network (CNN) which is known as deep learning architecture, has achieved impressive results in many applications. CNNs generally suffer from tuning a huge number of parameters which bring a great amount of complexity to the system. In addition, the initialization of the weights of the CNN is another handicap that needs to be handle carefully. In this paper, transfer learning and deep feature extraction methods are used which adapt a pre-trained CNN model to the problem at hand. AlexNet and Vgg16 models are considered in the presented work for feature extraction and AlexNet is used for further fine-tuning. The obtained features are then classified by support vector machines (SVM). Extensive experiments on a publicly available histopathologic breast cancer dataset are carried out and the accuracy scores are calculated for performance evaluation. The evaluation results show that the transfer learning produced better result than deep feature extraction and SVM classification.

Keywords

Breast cancer detection Histopathologic image Convolutional neural networks Transfer learning Deep feature extraction 

Notes

References

  1. 1.
    American Cancer Society. About breast cancer. https://www.cancer.org/content/dam/CRC/PDF/Public/8577.00.pdf.
  2. 2.
  3. 3.
    Wang L. Early diagnosis of breast cancer. Sensors. 2017;17–1572:1–20.Google Scholar
  4. 4.
  5. 5.
    Joy JE, et al., editors. Saving women’s lives: strategies for improving breast cancer detection and diagnosis. Washington, DC: Natl Acad Press; 2005.Google Scholar
  6. 6.
    Spanhol FA, Oliveira LS, Petitjean C, Heutte L. A dataset for breast cancer histopathological image classification. IEEE Trans Biomed Eng. 2016;63(7):1455–62.CrossRefGoogle Scholar
  7. 7.
    Gurcan MN, et al. Histopathological image analysis: a review. IEEE Rev Biomed Eng. 2009;2:147–71.CrossRefGoogle Scholar
  8. 8.
    Pearce C. Convolutional neural networks and the analysis of cancer imagery. Stanford University; 2017.Google Scholar
  9. 9.
    Selvathi D, Poornila A. Aarthy, “Breast cancer detection ın mammogram ımages using deep learning technique” middle-east. J Sci Res. 2017;25(2):417–26.Google Scholar
  10. 10.
    Geras KJ, et al. High-resolution breast cancer screening with multi-view deep convolutional neural networks. 2017. arXiv preprint arXiv:1703.07047.
  11. 11.
    Bayramoglu N, Kannala J, Heikkilä J. Deep learning for magnification independent breast cancer histopathology image classification. In: 2016 23rd International conference on pattern recognition (ICPR), pp. 2440–2445. IEEE. 2016.Google Scholar
  12. 12.
  13. 13.
    Krizhevsky A, Sutskever I, Hinton GE. Imagenet classification with deep convolutional neural networks. In: Advances in neural information processing systems, pp. 1106–1114. 2012.Google Scholar
  14. 14.
    Simonyan K, Zisserman A. Very deep convolutional networks for large-scale image recognition. Computing research repository (CoRR), vol. abs/1409.1556. 2014.Google Scholar
  15. 15.
    Orenstein EC, Beijbom O. Transfer learning and deep feature extraction for planktonic image data sets. In: 2017 IEEE Winter conference on applications of computer vision (WACV). IEEE. 2017.Google Scholar
  16. 16.
    Russakovsky O, et al. Imagenet large scale visual recognition challenge. Int J Comput Vis. 2015;115(3):211–52.MathSciNetCrossRefGoogle Scholar
  17. 17.
    Hearst MA, Dumais ST, Osuna E, Platt J, Scholkopf B. Support vector machines. In: IEEE intelligent systems and their applications, vol 13(4), pp. 18–28. July–Aug 1998.CrossRefGoogle Scholar
  18. 18.
    Vedaldi Andrea, Zisserman Andrew. Efficient additive kernels via explicit feature maps. IEEE Trans Pattern Anal Mach İntell. 2012;34(3):480–92.CrossRefGoogle Scholar
  19. 19.
    Spanhol F, Oliveira LS, Petitjean C, Heutte L. Breast cancer histopathological image classification using convolutional neural network. In: International joint conference on neural networks (IJCNN 2016), Vancouver, Canada, 2016.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Technology Faculty, Electrical and Electronics Engineering DepartmentFirat UniversityElazigTurkey
  2. 2.Department of Computer ScienceUniversity of Illinois at SpringfieldSpringfieldUSA
  3. 3.Discipline of Electronics and Communication EngineeringPDPM Indian Institute of Information Technology, Design and ManufacturingJabalpurIndia
  4. 4.Electrical and Electronics Engineering Department, Engineering FacultyBitlis Eren UniversityBitlisTurkey

Personalised recommendations