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Biological Theory

, Volume 6, Issue 1, pp 25–35 | Cite as

Regeneration and Development in Animals

  • Michel Vervoort
Original Paper

Abstract

Regeneration capabilities are found in most or all animals. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. If we consider regeneration as a process belonging to development, similarly to embryogenesis or metamorphosis, the existence of regenerative capabilities in adults can be seen as an argument in favor of the theory that development continues throughout the life of animals. Here I perform a comparative analysis of regeneration versus “classical” developmental processes in animals in order to determine to what extent these processes are inclusive or distinct. I identify the existence of regeneration-specific processes, i.e., processes that occur during the regeneration, but not the initial development, of a given structure. In addition, I find that seemingly similar processes acting during development and regeneration may have differential molecular and cellular bases. I thus conclude that there are significant differences between regeneration processes in adult animals and developmental processes occurring during earlier phases of the life cycle. The existence of regenerative capabilities in adult animals can therefore not be used as an argument in favor of the idea that development spans the whole life.

Keywords

Cell differentiation Dedifferentiation Development Epimorphosis Molecular mechanisms Regeneration Stem cells 

Notes

Acknowledgments

I am grateful to Pierre Kerner, Lucie Laplane, Michel Morange, Antonine Nicoglou, Thomas Pradeu, and Frédérique Théry for useful discussions and critical reading of this manuscript. My work was supported by the CNRS and the Institut Universitaire de France.

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Copyright information

© Konrad Lorenz Institute 2011

Authors and Affiliations

  1. 1.Institut Jacques MonodUniversité Paris Diderot and CNRSParisFrance
  2. 2.Institut Universitaire de FranceParisFrance

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