Abstract
A fast and convenient method for synthesis of some new functionalized pyrrole derivatives have been described via a three-component reaction between arylglyoxals, Meldrum’s acid and ethyl 2-chloro-3-(arylamino)but-2-enoate derivatives in excellent yields. When a mixture of arylglyoxal, Meldrum’s acid and ethyl 2-chloro-3-(arylamino)but-2-enoats were stirred in ethanol as a green solvent at room temperature, after one hour a solid product was separated from the reaction mixture. Simple filtration of this solid and its washing with ethanol afforded pure products. The structure of the products was proved by elemental analysis and IR and NMR apectral data.
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Nezhad-shahrokhabadi, F., Anary-Abbasinejad, M. An efficient synthesis of polyfunctionalized pyrroles by three-component reaction of arylglyoxals, Meldrum’s acid and ethyl 2-chloro-3-(arylamino)but-2-enoates. J IRAN CHEM SOC 19, 2655–2661 (2022). https://doi.org/10.1007/s13738-021-02485-5
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DOI: https://doi.org/10.1007/s13738-021-02485-5