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The effect of PVP application on Mebendazole release from electrospun nanofibers, kinetic study and thermodynamic analysis

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Abstract

Hydatid cyst is a common disease between humans and canines. Mebendazole has been used to treat this disease. Understanding and upgrading Mebendazole drug delivery system are the aim of this study. In this study, nanofibers containing drugs were fabricated by electrospinning. In the structure of nanofibers, polyvinylpyrrolidone (PVP) polymer is used as a drug release controller. In vitro, the living protoscoleces were exposed to nanofibers and the controlling effect of PVP was monitored using live protoscoleces mortality observation. The study found that PVP could be an effective controller of Mebendazole release from nanofiber. The higher the amount of PVP in the nanofibers, the lower the drug release rate and consequently the protoscoleces mortality rate decreases. Based on the statistical results of mortality, protoscoleces showed that PVP had significant controlling effects (p < 0.05). Kinetics and thermodynamic studies of the Mebendazole drug release process from nanofiber were performed. It was found that the release is carried out by the diffusion mechanism and the Sahlin–Peppas model describes the experimental data better than the other models. The thermodynamic parameters indicate that the enthalpy changes (ΔH > 0) are positive and that the process is endothermic. Entropy changes (ΔS < 0) indicate an increase in system disorder during drug release, and Gibbs free energy changes (ΔG > 0) indicate that drug release from the nanofibers is not spontaneous. Nanofibers that have more controller have a larger activation energy (Ea).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arāk, Iran

    Fatemeh Tavakoli & Hadi Shafiei

  2. Department of Parasitology and Mycology, School of Medicine, Arak University of Medical Sciences, Arāk, Iran

    Reza Ghasemikhah

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  1. Fatemeh Tavakoli
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  2. Hadi Shafiei
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  3. Reza Ghasemikhah
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Correspondence to Hadi Shafiei.

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Tavakoli, F., Shafiei, H. & Ghasemikhah, R. The effect of PVP application on Mebendazole release from electrospun nanofibers, kinetic study and thermodynamic analysis. J IRAN CHEM SOC 18, 1093–1102 (2021). https://doi.org/10.1007/s13738-020-02090-y

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