Skip to main content
SpringerLink
Log in

Decorations of graphene oxide with cisplatin toward investigation of fluorescence quencher on regulatory sequence of BRCA1 and BRCA2

  • Original Paper
  • Published:
Journal of the Iranian Chemical Society Aims and scope Submit manuscript

Abstract

Herein, we investigated the interaction of cisplatin loaded on GO (GO@CDDP) with two regulatory sequences, BRCA1 and BRCA2, synthesized from ssDNA based on agarose gel electrophoresis and fluorescence spectroscopy. For this reason, the GO nanosheets were prepared by exfoliating graphite according to the modified Hummer’s method and then the anticancer drug of CDDP was loaded on GO. Inductively coupled plasma analysis of the GO/CDDP indicated that the CDDP adsorbed on GO. The results showed that the efficiency of GO@CDDP in the quenching of sequence synthesized was significantly reduced compared to cisplatin. Furthermore, it was observed that the interaction of BRCA1 with GO@CDDP is slightly stronger than BRCA2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. L. Pecorino, Molecular biology of cancer: mechanisms, targets, and therapeutics (Oxford University Press, Oxford, 2012)

    Google Scholar 

  2. K. Haume, S. Rosa, S. Grellet, M.A. Smialek, K.T. Butterworth, A.V. Solovyov, K.M. Prise, J. Golding, N.J. Mason, Cancer Nanotechnol. 7, 8 (2016)

    Article  Google Scholar 

  3. E. Katz, I. Willner, ChemPhysChem 5, 1084 (2004)

    Article  CAS  Google Scholar 

  4. Z. Wu, Z. Zhen, J.H. Jiang, G.L. Shen, R.Q. Yu, J. Am. Chem. Soc. 131, 12325 (2009)

    Article  CAS  Google Scholar 

  5. M.E. Hughes, E. Brandin, J.A. Golovchenko, Nano Lett. 7, 1191 (2007)

    Article  CAS  Google Scholar 

  6. Y. Wang, Z. Li, J. Wang, J. Li, Y. Lin, Trends Biotechnol. 29, 205 (2011)

    Article  Google Scholar 

  7. K.S. Novoselov, A.K. Geim, S.V. Morozov, D. Jiang, Y. Zhang, S.V. Dubonos, I.V. Grigorieva, A.A. Firsov, Science 306, 666 (2004)

    Article  CAS  Google Scholar 

  8. M.J. Allen, V.C. Tung, R.B. Kaner, Chem. Rev. 110, 132 (2009)

    Article  Google Scholar 

  9. K.S. Novoselov, A.K. Geim, S.V. Morozov, D. Jiang, M.I. Katsnelson, I.V. Grigorieva, S.V. Dubonos, A.A. Firsov, Nature 438, 197 (2005)

    Article  CAS  Google Scholar 

  10. H. Tabani, K. Khodaei, A. Zeraatkar Moghaddam, M. Alexovič, S. Kazemi Movahed, F. Dorabadi Zare, M. Dabiri, Res. Chem. Intermed. 45(4), 1795 (2018)

    Article  Google Scholar 

  11. S. Bykkam, K. Rao, C. Chakra, T. Thunugunta, Int. J. Adv. Biotechnol. Res. 4, 142 (2013)

    Google Scholar 

  12. D.R. Dreyer, S. Park, C.W. Bielawski, R.S. Ruo, Chem. Soc. Rev. 39, 228 (2010)

    Article  CAS  Google Scholar 

  13. V. Georgakilas, M. Otyepka, A.B. Bourlinos, V. Chandra, N. Kim, K.C. Kemp, P. Hobza, R. Zboril, K.S. Kim, Chem. Rev. 112, 6156 (2012)

    Article  CAS  Google Scholar 

  14. L. Zhang, J. Xia, Q. Zhao, L. Liu, Z. Zhang, Small 6, 537 (2010)

    Article  CAS  Google Scholar 

  15. V.C. Sanchez, A. Jachak, R.H. Hurt, A.B. Kane, Chem. Res. Toxicol. 25, 15 (2011)

    Article  Google Scholar 

  16. O. Akhavan, E. Ghaderi, A. Esfandiar, J. Phys. Chem. B 115, 6279 (2011)

    Article  CAS  Google Scholar 

  17. Y. He, B. Jiao, H. Tang, RSC Adv. 4, 18294 (2014)

    Article  CAS  Google Scholar 

  18. H. Chang, L. Tang, Y. Wang, J. Jiang, J. Li, Anal. Chem. 82, 2341 (2010)

    Article  CAS  Google Scholar 

  19. X.H. Zhao, R.M. Kong, X.B. Zhang, H.M. Meng, W.N. Liu, W. Tan, G.L. Shen, R.Q. Yu, Anal. Chem. 83, 5062 (2011)

    Article  CAS  Google Scholar 

  20. M. Wu, R. Kempaiah, P.J.J. Huang, V. Maheshwari, J. Liu, Langmuir 27, 2731 (2011)

    Article  CAS  Google Scholar 

  21. L. Tang, H. Chang, Y. Liu, J. Li, Adv. Funct. Mater. 22, 3083 (2012)

    Article  CAS  Google Scholar 

  22. D.P. Bancroft, C.A. Lepre, S.J. Lippard, J. Am. Chem. Soc. 112, 6860 (1990)

    Article  CAS  Google Scholar 

  23. G.B. Onoa, G. Cervantes, V. Moreno, M.J. Prieto, Nucleic Acids Res. 26, 1473 (1998)

    Article  CAS  Google Scholar 

  24. M.H. Baik, R.A. Friesner, S.J. Lippard, J. Am. Chem. Soc. 125, 14082 (2003)

    Article  CAS  Google Scholar 

  25. Y. Mantri, S.J. Lippard, M.H. Baik, J. Am. Chem. Soc. 129, 5023 (2007)

    Article  CAS  Google Scholar 

  26. X. Xue, M.D. Hall, Q. Zhang, P.C. Wang, M.M. Gottesman, X.J. Liang, ACS Nano 7, 10452 (2013)

    Article  CAS  Google Scholar 

  27. L. Shahriary, A.A. Athawale, Int. J. Renew. Energy Environ. Eng. 2, 58 (2014)

    Google Scholar 

  28. X.C. Qin, Z.Y. Guo, Z.M. Liu, W. Zhang, M.M. Wan, B.W. Yang, J. Photochem. Photobiol. B 120, 156–162 (2013)

    Article  CAS  Google Scholar 

  29. H. Wang, W. Gu, N. Xiao, L. Ye, Q. Xu, Int. J. Nanomed. 9, 1433–1442 (2014)

    Google Scholar 

  30. L. Tian, X. Pei, Y. Zeng, R. He, Z. Li, J. Wang, Q. Wan, X. Li, J. Nanopart. Res. 16, 2709 (2014)

    Article  Google Scholar 

  31. Y. Lv, L. Tao, S.W. Annie Bligh, H. Yanga, Q. Pan, L. Zhu, Mater. Sci. Eng. C 59, 652–660 (2016)

    Article  CAS  Google Scholar 

  32. R.K. Thapa, H.-G. Choi, C.S. Yong, J.O. Kim, Colloids Surf. B 143, 271–277 (2016)

    Article  CAS  Google Scholar 

  33. A. Deb, N.G. Andrews, V. Raghavan, Int. J. Biol. Macromol. 113, 515–525 (2018)

    Article  CAS  Google Scholar 

  34. S.A. Makharza, G. Cirillo, O. Vittorio, E. Valli, F. Voli, A. Farfalla, M. Curcio, F. Iemma, F.P. Nicoletta, A.A. El-Gendy, G.F. Goya, S. Hampel, Pharmaceuticals 12(2), 76 (2019)

    Article  CAS  Google Scholar 

  35. J. Charmi, H. Nosrati, J. Mostafavi Amjad, R. Mohammadkhani, H. Danafar, Heliyon 5(4), 01466 (2019)

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank Dr. Jafarian’s biochemistry research group for their great help and Dr. Hassani’s laboratory for rapid progress in this work.

Author information

Authors and Affiliations

  1. Department of Physics, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran

    Parisa Smailii, Raziye Pakroo & Ramin Mohammadkhani

  2. Department of Biology, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran

    Vahab Jafarian

  3. Department of Chemistry, Faculty of Sciences, University of Zanjan, Zanjan, 45371-38791, Iran

    Farhad Kabiri Esfahani

  4. Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan, 45137-66731, Iran

    Leila Hassani

Authors
  1. Parisa Smailii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raziye Pakroo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ramin Mohammadkhani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vahab Jafarian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Farhad Kabiri Esfahani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Leila Hassani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ramin Mohammadkhani, Vahab Jafarian or Farhad Kabiri Esfahani.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smailii, P., Pakroo, R., Mohammadkhani, R. et al. Decorations of graphene oxide with cisplatin toward investigation of fluorescence quencher on regulatory sequence of BRCA1 and BRCA2. J IRAN CHEM SOC 17, 127–134 (2020). https://doi.org/10.1007/s13738-019-01762-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13738-019-01762-8

Keywords

Search

Navigation