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Synthesis of pyrazol-quinazolinones and 2,3-dihydroquinazolin-4(1H)-ones using CoAl2O4 nanoparticles as heterogeneous catalyst

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Abstract

The preparation and characterization of cobalt aluminate (CoAl2O4) magnetic nanoparticles and its application as a catalyst for the synthesis of a novel class of pyrazol-quinazolinones and 2,3-dihydroquinazolin-4(1H)-ones is described. The structure of the catalyst was studied by Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction, and vibrating sample magnetometer analysis. The resulting cobalt aluminate (CoAl2O4) was an efficient catalyst and affords the desired products in good to excellent yields. Moreover, the catalyst could be easily recovered by magnetic separation and recycled for four times without significant loss of its catalytic activity.

Graphic abstract

2,3-Dihydroquinazolin-4(1H)-ones and a novel class of pyrazol-quinazolinones were synthesized through one-pot condensation reaction of isatoic anhydride, aromatic aldehydes, and amines using CoAl2O4 as nanoparticle heterogeneous catalyst in refluxing ethanol.

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Acknowledgements

We are thankful to Persian Gulf University Research Council for partial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    Fatemeh Ahmadian, Alireza Barmak, Masoumeh Bavadi & Khodabakhsh Niknam

  2. Faculty of Chemistry, Bu-Ali Sina University, PO Box 6517838683, Hamedan, Iran

    Esmali Ghaderi

  3. Department of Physics, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    Hossein Raanaei

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  1. Fatemeh Ahmadian
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Correspondence to Khodabakhsh Niknam.

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Ahmadian, F., Barmak, A., Ghaderi, E. et al. Synthesis of pyrazol-quinazolinones and 2,3-dihydroquinazolin-4(1H)-ones using CoAl2O4 nanoparticles as heterogeneous catalyst. J IRAN CHEM SOC 16, 2647–2658 (2019). https://doi.org/10.1007/s13738-019-01729-9

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