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Efficient synthesis of α-aminonitriles over homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H), as a reusable acid catalyst

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Abstract

Good to excellent yields of α-aminonitriles are achieved through three-component Strecker reaction of aldehydes or ketones with amines and trimethylsilyl cyanides over homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H). The advantages of this protocol include: simplicity, short reaction time, high yields, ease of product isolation and reusability of the catalyst.

Graphical abstract

MSNs-HPZ-SO3H is prepared as an acid catalyst and successfully used for three-component Strecker reaction of aldehydes or ketones with amines and trimethylsilyl cyanides (TMSCN) under solvent-free conditions, a straightforward strategy for the synthesis of α-aminonitriles.

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Authors and Affiliations

  1. Department of Chemistry, Tarbiat Modares University, P.O.Box 14155-175, Tehran, Iran

    Zahra Nasresfahani, Mohamad Z. Kassaee & Esmaiel Eidi

  2. Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37240, USA

    Mohamad Z. Kassaee

Authors
  1. Zahra Nasresfahani
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  2. Mohamad Z. Kassaee
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  3. Esmaiel Eidi
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Correspondence to Mohamad Z. Kassaee.

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Mohamad Z. Kassaee: Visiting Scholar (sabbatical).

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Nasresfahani, Z., Kassaee, M.Z. & Eidi, E. Efficient synthesis of α-aminonitriles over homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H), as a reusable acid catalyst. J IRAN CHEM SOC 16, 1819–1825 (2019). https://doi.org/10.1007/s13738-019-01654-x

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  • DOI: https://doi.org/10.1007/s13738-019-01654-x

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