Abstract
A convenient and straightforward acid-promoted synthesis of a new series of polyfunctionalized pyrroles has been developed based on a one-pot three-component reaction of acetoacetanilide, benzoin, and ammonium acetate/diverse anilines in acetic acid as a green solvent at 100 °C. The other salient benefits of this transformation include being simple reaction conditions, toxic transition-metal-free, no need of column chromatographic purification, moderate to good yields, eco-friendliness, and readily available starting materials.
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We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.
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Fatahpour, M., Hazeri, N., Maghsoodlou, M.T. et al. Metal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction. J IRAN CHEM SOC 16, 111–116 (2019). https://doi.org/10.1007/s13738-018-1486-9
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DOI: https://doi.org/10.1007/s13738-018-1486-9