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Journal of the Iranian Chemical Society

, Volume 15, Issue 7, pp 1639–1645 | Cite as

Synthesis and cyclization of β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity

  • Wesam S. Shehab
  • Gehan T. El-Bassyouni
Original Paper

Abstract

Synthesis of biologically active new indole and pyrazole derivatives has earned a substantial position in the pharmaceutical industry. The study aims to synthesize and cyclize β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity. Novel derivatives of enolic keto ester 1 have been obtained through Claisen condensation of 3-acetylindole with diethyl oxalate under basic conditions. Spectral data of newly produced compounds were characterized using Fourier transform infrared, hydrogen nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance, and elemental analysis. Few compounds were assessed for their antimicrobial activity, contrary to gram-positive bacterial strains, gram-negative bacterial strain, and antifungal activity that have been approved against Candida albicans. However, compound 2 showed an excellent antimicrobial activity. In vitro antitumor action of few prepared compounds in contradiction to human breast carcinoma cell line, colon cell line, and normal retina cell line was evaluated.

Graphical Abstract

Keywords

Antimicrobial Anticancer Cyclization Derivatives Pyrazole 

Notes

Acknowledgements

The authors are very thankful to all the associated personnel in any reference that contributed in/for the purpose of this research.

Compliance with ethical standards

Conflict of interest

All the authors declare that they have no conflict of interest.

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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of ScienceZagazig UniversityZagazigEgypt
  2. 2.Refractories, Ceramics and Building Materials DepartmentNational Research Centre (NRC)Dokki, GizaEgypt

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