Journal of the Iranian Chemical Society

, Volume 15, Issue 7, pp 1633–1637 | Cite as

Synthesis of spiro[pyrazoloquinoline-oxindoles] and spiro[chromenopyrazolo-oxindoles] promoted by guanidine-functionalized magnetic Fe3O4 nanoparticles

Original Paper
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Abstract

Magnetic nanoparticles (MNPs) Fe3O4-immobilized guanidine (Fe3O4 MNPs-guanidine) have been used as an efficient catalyst for the preparation of spiro[pyrazoloquinoline-oxindoles] and spiro[chromenopyrazolo-oxindoles] by four-component reactions of phenylhydrazine or hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux condition in ethanol. This method provides several advantages including mild reaction conditions, the applicability to a wide range of substrates, the reusability of the catalyst and low catalyst loading.

Keywords

Fe3O4 nanoparticles Heterogeneous catalyst Spirooxindoles One pot reaction 

Notes

Acknowledgements

The authors gratefully acknowledge the financial support of this work by the Research Affairs Office of the Islamic Azad University Tehran Branch, Tehran, I. R. Iran.

Supplementary material

13738_2018_1361_MOESM1_ESM.docx (965 kb)
Supplementary material 1 (DOCX 965 kb)

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Copyright information

© Iranian Chemical Society 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Science and Research BranchIslamic Azad UniversityTehranIran

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