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Synthesis of spiro[pyrazoloquinoline-oxindoles] and spiro[chromenopyrazolo-oxindoles] promoted by guanidine-functionalized magnetic Fe3O4 nanoparticles

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Abstract

Magnetic nanoparticles (MNPs) Fe3O4-immobilized guanidine (Fe3O4 MNPs-guanidine) have been used as an efficient catalyst for the preparation of spiro[pyrazoloquinoline-oxindoles] and spiro[chromenopyrazolo-oxindoles] by four-component reactions of phenylhydrazine or hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux condition in ethanol. This method provides several advantages including mild reaction conditions, the applicability to a wide range of substrates, the reusability of the catalyst and low catalyst loading.

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Acknowledgements

The authors gratefully acknowledge the financial support of this work by the Research Affairs Office of the Islamic Azad University Tehran Branch, Tehran, I. R. Iran.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Fatemeh Alemi Tameh & Javad Safaei-Ghomi

Authors
  1. Fatemeh Alemi Tameh
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  2. Javad Safaei-Ghomi
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Correspondence to Javad Safaei-Ghomi.

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Alemi Tameh, F., Safaei-Ghomi, J. Synthesis of spiro[pyrazoloquinoline-oxindoles] and spiro[chromenopyrazolo-oxindoles] promoted by guanidine-functionalized magnetic Fe3O4 nanoparticles. J IRAN CHEM SOC 15, 1633–1637 (2018). https://doi.org/10.1007/s13738-018-1361-8

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  • DOI: https://doi.org/10.1007/s13738-018-1361-8

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