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Rapid, green, and catalyst-free one-pot three-component syntheses of 5-substituted 1H-tetrazoles in magnetized water

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Abstract

The catalyst-free multi-component reactions of aldehydes, malononitrile, and sodium azide at a relatively low temperature in magnetized water provided 5-substituted 1H-tetrazoles in high-to-excellent yields. This method offers the advantages of short reaction times, low costs, quantitative reaction yields, simple work-up, green, and no need for any organic solvent.

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Acknowledgement

We gratefully acknowledge the financial support of the Research Council of the Shahrood University of Technology.

Author information

Authors and Affiliations

  1. School of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran

    Mohammad Bakherad, Rahele Doosti & Ali Keivanloo

  2. Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, 91779, Iran

    Mostafa Gholizadeh

  3. Department of Chemistry, Shahid Beheshti University, Tehran, 1983963113, Iran

    Khosrow Jadidi

Authors
  1. Mohammad Bakherad
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  2. Rahele Doosti
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  3. Ali Keivanloo
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  4. Mostafa Gholizadeh
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  5. Khosrow Jadidi
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Corresponding author

Correspondence to Mohammad Bakherad.

Electronic supplementary material

Below is the link to the electronic supplementary material.

13738_2017_1193_MOESM1_ESM.docx

The supporting information for this work is available, as follows: copies of 1H and 13C spectra of all the new 5-substituted 1H-tetrazoles. (DOCX 3003 kb)

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Bakherad, M., Doosti, R., Keivanloo, A. et al. Rapid, green, and catalyst-free one-pot three-component syntheses of 5-substituted 1H-tetrazoles in magnetized water. J IRAN CHEM SOC 14, 2591–2597 (2017). https://doi.org/10.1007/s13738-017-1193-y

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  • DOI: https://doi.org/10.1007/s13738-017-1193-y

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