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Journal of the Iranian Chemical Society

, Volume 14, Issue 5, pp 1131–1137 | Cite as

Sequential one-pot five-component synthesis of tetrazole-based spirotetrahydro-β-carbolines

  • Mehdi Ghandi
  • Mahdieh Mahami Ahangaran
  • Alireza Abbasi
Original Paper

Abstract

A one-pot five-component two-step sequential synthesis of tetrazole-based tetrahydrospiro[indene-2,1′-pyrido[3,4-b]indole]-1,3-diones in moderate to good yields is described. The reaction consists of four-component condensation of aromatic aldehydes with tryptamine, trimethylsilyl azide (TMSN3) and isocyanides, followed by addition of ninhydrin. These reactions presumably proceeded through Ugi-azide/Pictet–Spengler processes, respectively.

Keywords

Tetrazole Ugi-azide Pictet–Spengler Spiro[indene-2,1′-pyrido[3,4-b]indole]-1,3-diones 

Notes

Acknowledgement

The authors acknowledge the University of Tehran for financial support of this research.

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Copyright information

© Iranian Chemical Society 2017

Authors and Affiliations

  • Mehdi Ghandi
    • 1
  • Mahdieh Mahami Ahangaran
    • 1
  • Alireza Abbasi
    • 1
  1. 1.School of Chemistry, College of ScienceUniversity of TehranTehranIran

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